DegronMD

Uniprot ID: Q96PU5

Source protein: E3 ubiquitin-protein ligase NEDD4-like

Source gene: NEDD4L

Class: DEG_SPOP_SBC_1

Location: 363:367

E3 ligase: SPOP

DEGRON score: 0.9797

ASA_SCORE: 73.34

COIL: 0.7298

CONS_SCORE: 0.4079

DSS_SCORE: 0.7491

HELIX: 0.0384

FCONS_SCORE: 0.9935

RIG_SCORE: 0.5965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R364C	TCGA-32-2616	GBM	TCGA	ARSST	DEG_SPOP_SBC_1	0.719
p.R364C	TCGA-FI-A2D5	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.719
p.P355S	TCGA-A5-A0G2	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.1111
p.P355S	DO41235	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1111
p.R364H	TCGA-AG-A02N	READ	TCGA	ARSST	DEG_SPOP_SBC_1	0.7133
p.R364H	TCGA-AU-6004	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.7133
p.T375M	TCGA-AP-A059	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.5556
p.T369M	TCGA-HU-A4H3	STAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.7222
p.T369M	SIDM00910	Neuroblastoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7222
p.T369M	SIDM01578	Bladder Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7222
p.T369M	ACH-000120	Neuroblastoma	CCLE	ARSST	DEG_SPOP_SBC_1	0.7222
p.T369M	ACH-000862	Bladder Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.7222
p.T369M	CHP-212	autonomic_ganglia	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7222
p.A361V	DO219724	CESC	ICGC	ARSST	DEG_SPOP_SBC_1	0.2778
p.R356C	DO13462	GBM	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.R356C	DO41331	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1389
p.A357S	DO228546	LICA	ICGC	ARSST	DEG_SPOP_SBC_1	0.6111
p.L372I	DO230961	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.L372I	DO224594	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.S362P	DO37976	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.3056
p.P359T	DO38075	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.2222
p.A363V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.5825
p.P365Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7035
p.Q370H	UACC-62	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	0.25
p.Q370H	UACC-257	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	0.25
p.P361S	CL-34	large_intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	0.2778
p.P377Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	0.5
p.P357Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	0.6111
p.T361M	CHP-212	autonomic_ganglia	COSMIC	ARSST	DEG_SPOP_SBC_1	0.2778
p.R372C	HCC2998	large_intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSST

Degron related mutations and impact score

Drug responses associated with NEDD4L mutations

All proteins holding degron of ARSST