DegronMD - Q96PU5(NEDD4L)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R364C	TCGA-32-2616	GBM	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.719
p.R364C	TCGA-FI-A2D5	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.719
p.R253W	TCGA-44-3398	LUAD	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.0833
p.R253W	DO25030	LUAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.0833
p.W221C	TCGA-49-AARO	LUAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.W221C	DO228948	LICA	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.W221C	DO218924	LUAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.S230F	TCGA-93-7347	LUAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6871
p.S230F	DO24364	LUAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6871
p.E279K	TCGA-A5-A0G2	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.E279K	TCGA-AA-A010	COAD	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.E279K	DO41235	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.P355S	TCGA-A5-A0G2	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.P355S	DO41235	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1111
p.R364H	TCGA-AG-A02N	READ	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7133
p.R364H	TCGA-AU-6004	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7133
p.T375M	TCGA-AP-A059	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.5556
p.Q239R	TCGA-AP-A1DK	UCEC	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.Q239R	DO42033	UCEC	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.0833
p.R217W	TCGA-AX-A2HD	UCEC	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.R217W	DO42608	UCEC	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.G266R	TCGA-BC-A10U	LIHC	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.6457
p.G266R	DO22926	LIHC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.6457
p.S256R	TCGA-BG-A0M4	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1667
p.E232K	TCGA-D9-A149	SKCM	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2778
p.E232K	DO37420	SKCM	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.2778
p.S256G	TCGA-DI-A1BU	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1667
p.S256G	DO42023	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1667
p.N235I	TCGA-HU-A4GX	STAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.N235I	DO47757	STAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.1944
p.T369M	TCGA-HU-A4H3	STAD	TCGA	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.T369M	SIDM00910	Neuroblastoma	GDSC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.T369M	SIDM01578	Bladder Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.T369M	ACH-000120	Neuroblastoma	CCLE	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.T369M	ACH-000862	Bladder Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.T369M	CHP-212	autonomic ganglia	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.7222
p.V229M	DO222955	BTCA	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.6097
p.A361V	DO219724	CESC	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.S268L	DO219749	CESC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7667
p.R279C	DO8018	COAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.R279C	DO9114	COAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.R279C	DO48290	ESCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.R279C	DO41199	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.R279C	HCC2998	large intestine	COSMIC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1389
p.E271K	DO222762	COCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7022
p.T263M	DO233245	GACA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7423
p.R356C	DO13462	GBM	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.R356C	DO41331	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1389
p.A357S	DO228546	LICA	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.6111
p.W273L	DO228974	LICA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.3056
p.E266D	DO229015	LICA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.6758
p.S221N	DO48721	LIRI	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.L372I	DO230961	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.L372I	DO224594	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944
p.E262K	DO27953	ORCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7022
p.E262K	DO35988	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7022
p.A282V	DO46657	PAAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.0556
p.E257V	DO227527	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1944
p.P264L	DO232761	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7582
p.S362P	DO37976	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.3056
p.P359T	DO38075	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2222
p.T254M	DO41361	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1111
p.T280A	DO41331	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1111
p.S233L	SIDM01278	Colorectal Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S233L	SIDM00222	Mesothelioma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S233L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S233L	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S233L	SIDM00077	Oral Cavity Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.25
p.S264W	SIDM01037	Breast Carcinoma	GDSC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.6763
p.S264W	JIMT-1	breast	COSMIC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.6763
p.A363V	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.5825
p.S231L	SIDM00780	Colorectal Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.S231L	ACH-000967	Colon/Colorectal Cancer	CCLE	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation rewiring degron network	0.3056
p.S230P	ACH-001991	Primary	CCLE	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.5641
p.P365Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation altering degron motif	0.7035
p.P264Q	NCI-H146	lung	COSMIC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation altering degron motif	0.7035
p.Q370H	UACC-62	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.25
p.Q370H	UACC-257	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.25
p.P361S	CL-34	large intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.P377Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.5
p.A225T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7139
p.S256W	JIMT-1	breast	COSMIC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.1667
p.G230D	MKN45	stomach	COSMIC	HRPSLMDVS	DEG_APCC_DBOX_1	222:230	Mutation altering degron motif	0.7198
p.R259C	HCC2998	large intestine	COSMIC	EPSEGGDVPEP	DEG_COP1_1	262:272	Mutation rewiring degron network	0.25
p.P357Q	NCI-H146	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation blocking phosphorylation signal	0.6111
p.T361M	CHP-212	autonomic ganglia	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.2778
p.R372C	HCC2998	large intestine	COSMIC	ARSST	DEG_SPOP_SBC_1	363:367	Mutation rewiring degron network	0.1944

Kaplan plot for NEDD4L in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEDD4L

UniProt ID: Q96PU5

Entrez ID: 23327

Protein name: E3 ubiquitin-protein ligase NEDD4-like (EC 2.3.2.26) (EC 2.3.2.36) (HECT-type E3 ubiquitin transferase NED4L) (NEDD4.2) (Nedd4-2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NEDD4L in