DegronMD

Uniprot ID: Q96PU5

Source protein: E3 ubiquitin-protein ligase NEDD4-like

Source gene: NEDD4L

Class: DEG_APCC_DBOX_1

Location: 222:230

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9817

ASA_SCORE: 71.0556

COIL: 0.7584

CONS_SCORE: 0.5005

DSS_SCORE: 0.5375

HELIX: 0.0803

FCONS_SCORE: 0.9558

RIG_SCORE: 0.7336

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W221C	TCGA-49-AARO	LUAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.W221C	DO228948	LICA	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.W221C	DO218924	LUAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.S230F	TCGA-93-7347	LUAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.6871
p.S230F	DO24364	LUAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.6871
p.Q239R	TCGA-AP-A1DK	UCEC	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.0833
p.Q239R	DO42033	UCEC	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.0833
p.R217W	TCGA-AX-A2HD	UCEC	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.1944
p.R217W	DO42608	UCEC	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.1944
p.E232K	TCGA-D9-A149	SKCM	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.2778
p.E232K	DO37420	SKCM	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.2778
p.N235I	TCGA-HU-A4GX	STAD	TCGA	HRPSLMDVS	DEG_APCC_DBOX_1	0.1944
p.N235I	DO47757	STAD	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.1944
p.V229M	DO222955	BTCA	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.6097
p.S221N	DO48721	LIRI	ICGC	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.S233L	SIDM01278	Colorectal Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.25
p.S233L	SIDM00222	Mesothelioma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.25
p.S233L	SIDM00768	Non-Small Cell Lung Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.25
p.S233L	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.25
p.S233L	SIDM00077	Oral Cavity Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.25
p.S231L	SIDM00780	Colorectal Carcinoma	GDSC	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.S231L	ACH-000967	Colon/Colorectal Cancer	CCLE	HRPSLMDVS	DEG_APCC_DBOX_1	0.3056
p.S230P	ACH-001991	Primary	CCLE	HRPSLMDVS	DEG_APCC_DBOX_1	0.5641
p.A225T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	HRPSLMDVS	DEG_APCC_DBOX_1	0.7139
p.G230D	MKN45	stomach	COSMIC	HRPSLMDVS	DEG_APCC_DBOX_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_APCC_DBOX_1	222:230	HRPSLMDVS	APC,CDC20,FZR1	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRPSLMDVS

Degron related mutations and impact score

Drug responses associated with NEDD4L mutations

All proteins holding degron of HRPSLMDVS