DegronMD

Uniprot ID: Q96PU5

Source protein: E3 ubiquitin-protein ligase NEDD4-like

Source gene: NEDD4L

Class: DEG_COP1_1

Location: 262:272

E3 ligase: COP1

DEGRON score: 0.9007

ASA_SCORE: 81.9545

COIL: 0.9275

CONS_SCORE: 0.4237

DSS_SCORE: 0.7384

HELIX: 0.0435

FCONS_SCORE: 0.9252

RIG_SCORE: 0.5804

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R253W	TCGA-44-3398	LUAD	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.0833
p.R253W	DO25030	LUAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.0833
p.E279K	TCGA-A5-A0G2	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.E279K	TCGA-AA-A010	COAD	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.E279K	DO41235	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.G266R	TCGA-BC-A10U	LIHC	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.6457
p.G266R	DO22926	LIHC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.6457
p.S256R	TCGA-BG-A0M4	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.1667
p.S256G	TCGA-DI-A1BU	UCEC	TCGA	EPSEGGDVPEP	DEG_COP1_1	0.1667
p.S256G	DO42023	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1667
p.S268L	DO219749	CESC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7667
p.R279C	DO8018	COAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.R279C	DO9114	COAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.R279C	DO48290	ESCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.R279C	DO41199	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.R279C	HCC2998	large_intestine	COSMIC	EPSEGGDVPEP	DEG_COP1_1	0.1389
p.E271K	DO222762	COCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7022
p.T263M	DO233245	GACA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7423
p.W273L	DO228974	LICA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.3056
p.E266D	DO229015	LICA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.6758
p.E262K	DO27953	ORCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7022
p.E262K	DO35988	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7022
p.A282V	DO46657	PAAD	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.0556
p.E257V	DO227527	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1944
p.P264L	DO232761	PBCA	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.7582
p.T254M	DO41361	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1111
p.T280A	DO41331	UCEC	ICGC	EPSEGGDVPEP	DEG_COP1_1	0.1111
p.S264W	SIDM01037	Breast Carcinoma	GDSC	EPSEGGDVPEP	DEG_COP1_1	0.6763
p.S264W	JIMT-1	breast	COSMIC	EPSEGGDVPEP	DEG_COP1_1	0.6763
p.P264Q	NCI-H146	lung	COSMIC	EPSEGGDVPEP	DEG_COP1_1	0.7035
p.S256W	JIMT-1	breast	COSMIC	EPSEGGDVPEP	DEG_COP1_1	0.1667
p.R259C	HCC2998	large_intestine	COSMIC	EPSEGGDVPEP	DEG_COP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPSEGGDVPEP

Degron related mutations and impact score

Drug responses associated with NEDD4L mutations

All proteins holding degron of EPSEGGDVPEP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_COP1_1	262:272	EPSEGGDVPEP	COP1	0.9007	More...