DegronMD - Q5T619(ZNF648)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A484T	TCGA-90-7964	LUSC	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.A484T	DO27046	LUSC	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2778
p.H498N	TCGA-91-6829	LUAD	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1111
p.H498N	DO23564	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1111
p.S489L	TCGA-BR-8081	STAD	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	TCGA-EE-A3AE	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	DO220900	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	DO229456	SKCA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	DO37802	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	DO38795	STAD	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	SIDM01060	Melanoma	GDSC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	ACH-000882	Skin Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.S489L	IGR-1	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7667
p.R487S	TCGA-D3-A2JK	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.6316
p.R487S	DO37619	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.6316
p.P477S	TCGA-DA-A1I0	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.P477S	TCGA-DA-A3F8	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.P477S	TCGA-W3-A824	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.P477S	DO37719	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.P477S	DO37418	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.P477S	DO51271	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0833
p.C481Y	TCGA-EO-A22U	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.C481Y	DO43755	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.G482V	TCGA-ER-A19P	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2222
p.G482V	DO47623	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.2222
p.R493W	TCGA-FU-A3HZ	CESC	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.R493W	DO6308	CESC	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.R493W	SIDM01951	Colorectal Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.T479M	TCGA-G4-6628	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.T479M	DO10132	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.T479M	DO25847	LUAD	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.T479M	DO51496	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.T479M	SIDM00705	Non-Cancerous	GDSC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.T479M	SIDM00706	Small Cell Lung Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1389
p.G500R	DO218550	BTCA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0556
p.G500R	ACH-001573	Leukemia	CCLE	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.0556
p.R493Q	DO229378	BTCA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.R493Q	DO50328	ESAD	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.R493Q	DO233259	GACA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.R493Q	DO222470	MELA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.25
p.C478S	DO32893	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1111
p.C481R	DO35242	PACA	ICGC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation rewiring degron network	0.1944
p.R487H	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7133
p.R487H	ACH-000826	Lung Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7133
p.R487H	CAL-12T	lung	COSMIC	ARSST	DEG_SPOP_SBC_1	486:490	Mutation altering degron motif	0.7133

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF648

UniProt ID: Q5T619

Entrez ID: 127665

Protein name: Zinc finger protein 648

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF648 in