DegronMD

Uniprot ID: Q96BA8

Source protein: Cyclic AMP-responsive element-binding protein 3-like protein 1

Source gene: CREB3L1

Class: DEG_SPOP_SBC_1

Location: 235:239

E3 ligase: SPOP

DEGRON score: 0.7129

ASA_SCORE: 93.48

COIL: 0.9046

CONS_SCORE: 0.3925

DSS_SCORE: 0.66

HELIX: 0.0414

FCONS_SCORE: 0.983

RIG_SCORE: 0.6113

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P230H	TCGA-AZ-6601	COAD	TCGA	ARSST	DEG_SPOP_SBC_1	0.1944
p.P230H	DO8119	COAD	ICGC	ARSST	DEG_SPOP_SBC_1	0.1944
p.A235V	TCGA-B5-A3FC	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.5825
p.A235V	DO41871	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.5825
p.R236C	TCGA-FI-A2D0	UCEC	TCGA	ARSST	DEG_SPOP_SBC_1	0.719
p.R236C	DO233884	GACA	ICGC	ARSST	DEG_SPOP_SBC_1	0.719
p.R236C	DO43891	UCEC	ICGC	ARSST	DEG_SPOP_SBC_1	0.719
p.M234V	TCGA-GN-A4U8	SKCM	TCGA	ARSST	DEG_SPOP_SBC_1	0.3056
p.M234V	DO47320	SKCM	ICGC	ARSST	DEG_SPOP_SBC_1	0.3056
p.A249S	DO228948	LICA	ICGC	ARSST	DEG_SPOP_SBC_1	0.0556
p.R236H	DO228890	LICA	ICGC	ARSST	DEG_SPOP_SBC_1	0.7133
p.R236H	SIDM02049	Pancreatic Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7133
p.R236H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ARSST	DEG_SPOP_SBC_1	0.7133
p.R236H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7133
p.M234I	DO228978	LICA	ICGC	ARSST	DEG_SPOP_SBC_1	0.3056
p.T239M	SIDM01100	Neuroblastoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.8534
p.T239M	SIDM01609	Endometrial Carcinoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.8534
p.S238F	SIDM00149	Melanoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7982
p.S238F	ACH-000750	Skin Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.7982
p.S238F	LOXIMVI	skin	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7982
p.A235T	SIDM00242	Osteosarcoma	GDSC	ARSST	DEG_SPOP_SBC_1	0.7139
p.A235T	ACH-002067	Bone Cancer	CCLE	ARSST	DEG_SPOP_SBC_1	0.7139
p.A235T	NOS-1	bone	COSMIC	ARSST	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95817	BAG family molecular chaperone regulator 3	DEG_SPOP_SBC_1	281:285	ARSST	SPOP	0.9272	More...
P46019	Phosphorylase b kinase regulatory subunit alpha, liver isoform	DEG_SPOP_SBC_1	1037:1041	ARSST	SPOP	0.6157	More...
Q15788	Nuclear receptor coactivator 1	DEG_SPOP_SBC_1	401:405	ARSST	SPOP	0.9779	More...
Q5T619	Zinc finger protein 648	DEG_SPOP_SBC_1	486:490	ARSST	SPOP	0.9232	More...
Q96BA8	Cyclic AMP-responsive element-binding protein 3-like protein 1	DEG_SPOP_SBC_1	235:239	ARSST	SPOP	0.7129	More...
Q96PU5	E3 ubiquitin-protein ligase NEDD4-like	DEG_SPOP_SBC_1	363:367	ARSST	SPOP	0.9797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons