DegronMD - O60346(PHLPP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1106Q	TCGA-18-3421	LUSC	TCGA	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1667
p.I1477M	TCGA-25-1329	OV	TCGA	VPSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1389
p.V1088M	TCGA-2W-A8YY	CESC	TCGA	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1389
p.V1088M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1389
p.V1088M	SIDM01450	Gastric Carcinoma	GDSC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1389
p.P1467T	TCGA-2W-A8YY	CESC	TCGA	VPSSS	DEG_SPOP_SBC_1	1466:1470	Mutation altering degron motif	0.5919
p.E1100K	TCGA-AN-A046	BRCA	TCGA	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation altering degron motif	0.7022
p.D474N	DO48385	BLCA	ICGC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.6932
p.E445Q	DO51596	CESC	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	448:455	Mutation rewiring degron network	0.25
p.E445Q	DO223015	ESCA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	448:455	Mutation rewiring degron network	0.25
p.R1109W	DO49005	CESC	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.0833
p.D149Y	DO222884	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0833
p.S129L	DO234225	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1389
p.A136T	DO234336	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7139
p.A441S	DO228948	LICA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	448:455	Mutation rewiring degron network	0.1389
p.V454F	DO228985	LICA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7068
p.S475I	DO229031	LICA	ICGC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7341
p.H139R	DO50893	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.8244
p.G1093S	DO23374	LINC	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.2778
p.R126H	DO45059	LINC	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.E138V	DO26790	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation altering degron motif	0.7693
p.D474Y	DO50708	ORCA	ICGC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation altering degron motif	0.7325
p.G1104R	DO229470	SKCA	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.2222
p.P466Q	DO37851	SKCM	ICGC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.T450N	DO229257	THCA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	448:455	Mutation altering degron motif	0.7055
p.R1108C	DO43306	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation substituting flanking lysine	0.2222
p.A481T	DO42392	UCEC	ICGC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.25
p.L144V	DO43290	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation blocking phosphorylation signal	0.6667
p.D1090N	DO41644	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1944
p.L144I	DO41584	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation blocking phosphorylation signal	0.6667
p.G1104V	DO42504	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.2222
p.C134Y	DO42673	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.2778
p.E486D	SIDM00845	Burkitt's Lymphoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1111
p.E486D	SIDM00035	Thyroid Gland Carcinoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1111
p.E486D	SIDM00461	Acute Myeloid Leukemia	GDSC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1111
p.H1086Y	SIDM01090	Colorectal Carcinoma	GDSC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.0833
p.H1086Y	ACH-000943	Colon/Colorectal Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.0833
p.H1086Y	ACH-001786	Colon/Colorectal Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.0833
p.H1086Y	RKO	large intestine	COSMIC	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.0833
p.L483F	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1944
p.L483F	ACH-002253	Lymphoma	CCLE	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1944
p.L483F	JSC-1	haematopoietic and lymphoid tissue	COSMIC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1944
p.A485T	SIDM00982	Glioblastoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.A485T	ACH-000323	Brain Cancer	CCLE	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.A485T	42-MG-BA	central nervous system	COSMIC	VQLHGE	LIG_APCC_ABBA_1	473:478	Mutation rewiring degron network	0.1389
p.H150Q	ACH-000107	Pancreatic Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.0556
p.T1087I	ACH-000899	Skin Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	1095:1100	Mutation rewiring degron network	0.1111
p.A145T	ACH-000948	Gastric Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	136:140	Mutation rewiring degron network	0.1944
p.G1472S	ACH-001518	Endometrial/Uterine Cancer	CCLE	VPSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.2778
p.R1459W	ACH-001802	Liposarcoma	CCLE	VPSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1389
p.P1460S	ACH-001970	Metastasis	CCLE	VPSSS	DEG_SPOP_SBC_1	1466:1470	Mutation rewiring degron network	0.1667

Kaplan plot for PHLPP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHLPP1

UniProt ID: O60346

Entrez ID: 23239

Protein name: PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHLPP1 in