DegronMD

Uniprot ID: O60346

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 1

Source gene: PHLPP1

Class: LIG_APCC_ABBA_1

Location: 473:478

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9148

ASA_SCORE: 64.7667

COIL: 0.3825

CONS_SCORE: 0.2466

DSS_SCORE: 0.6346

HELIX: 0.0028

FCONS_SCORE: 0.8576

RIG_SCORE: 0.7368

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D474N	DO48385	BLCA	ICGC	VQLHGE	LIG_APCC_ABBA_1	0.6932
p.S475I	DO229031	LICA	ICGC	VQLHGE	LIG_APCC_ABBA_1	0.7341
p.D474Y	DO50708	ORCA	ICGC	VQLHGE	LIG_APCC_ABBA_1	0.7325
p.P466Q	DO37851	SKCM	ICGC	VQLHGE	LIG_APCC_ABBA_1	0.1389
p.A481T	DO42392	UCEC	ICGC	VQLHGE	LIG_APCC_ABBA_1	0.25
p.E486D	SIDM00845	Burkitt's Lymphoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	0.1111
p.E486D	SIDM00035	Thyroid Gland Carcinoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	0.1111
p.E486D	SIDM00461	Acute Myeloid Leukemia	GDSC	VQLHGE	LIG_APCC_ABBA_1	0.1111
p.L483F	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	0.1944
p.L483F	ACH-002253	Lymphoma	CCLE	VQLHGE	LIG_APCC_ABBA_1	0.1944
p.L483F	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VQLHGE	LIG_APCC_ABBA_1	0.1944
p.A485T	SIDM00982	Glioblastoma	GDSC	VQLHGE	LIG_APCC_ABBA_1	0.1389
p.A485T	ACH-000323	Brain Cancer	CCLE	VQLHGE	LIG_APCC_ABBA_1	0.1389
p.A485T	42-MG-BA	central_nervous_system	COSMIC	VQLHGE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	LIG_APCC_ABBA_1	473:478	VQLHGE	APC,CDC20,FZR1	0.9148	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons