DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
VQLHGE
Uniprot ID:
O60346
Source protein:
PH domain leucine-rich repeat-containing protein phosphatase 1
Source gene:
PHLPP1
Class:
LIG_APCC_ABBA_1
Location:
473:478
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9148
ASA_SCORE:
64.7667
COIL:
0.3825
CONS_SCORE:
0.2466
DSS_SCORE:
0.6346
HELIX:
0.0028
FCONS_SCORE:
0.8576
RIG_SCORE:
0.7368
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S475I
DO229031
LICA
ICGC
VQLHGE
LIG_APCC_ABBA_1
0.7341
p.D474Y
DO50708
ORCA
ICGC
VQLHGE
LIG_APCC_ABBA_1
0.7325
p.D474N
DO48385
BLCA
ICGC
VQLHGE
LIG_APCC_ABBA_1
0.6932
p.A481T
DO42392
UCEC
ICGC
VQLHGE
LIG_APCC_ABBA_1
0.25
p.L483F
SIDM00688
B-Cell Non-Hodgkin's Lymphoma
GDSC
VQLHGE
LIG_APCC_ABBA_1
0.1944
p.L483F
ACH-002253
Lymphoma
CCLE
VQLHGE
LIG_APCC_ABBA_1
0.1944
p.L483F
JSC-1
haematopoietic_and_lymphoid_tissue
COSMIC
VQLHGE
LIG_APCC_ABBA_1
0.1944
p.P466Q
DO37851
SKCM
ICGC
VQLHGE
LIG_APCC_ABBA_1
0.1389
p.A485T
SIDM00982
Glioblastoma
GDSC
VQLHGE
LIG_APCC_ABBA_1
0.1389
p.A485T
ACH-000323
Brain Cancer
CCLE
VQLHGE
LIG_APCC_ABBA_1
0.1389
p.A485T
42-MG-BA
central_nervous_system
COSMIC
VQLHGE
LIG_APCC_ABBA_1
0.1389
p.E486D
SIDM00845
Burkitt's Lymphoma
GDSC
VQLHGE
LIG_APCC_ABBA_1
0.1111
p.E486D
SIDM00035
Thyroid Gland Carcinoma
GDSC
VQLHGE
LIG_APCC_ABBA_1
0.1111
p.E486D
SIDM00461
Acute Myeloid Leukemia
GDSC
VQLHGE
LIG_APCC_ABBA_1
0.1111
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Drug responses associated with PHLPP1 mutations
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Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of VQLHGE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60346
PH domain leucine-rich repeat-containing protein phosphatase 1
LIG_APCC_ABBA_1
473:478
VQLHGE
APC,CDC20,FZR1
0.9148
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