DegronMD

Uniprot ID: O60346

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 1

Source gene: PHLPP1

Class: DEG_SCF_FBW7_1

Location: 448:455

E3 ligase: FBXW7

DEGRON score: 0.7016

ASA_SCORE: 76.5125

COIL: 0.6453

CONS_SCORE: 0.2636

DSS_SCORE: 0.6563

HELIX: 0.0444

FCONS_SCORE: 0.9487

RIG_SCORE: 0.5674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E445Q	DO51596	CESC	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	0.25
p.E445Q	DO223015	ESCA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	0.25
p.A441S	DO228948	LICA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	0.1389
p.V454F	DO228985	LICA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	0.7068
p.T450N	DO229257	THCA	ICGC	LQSTPGRS	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	DEG_SCF_FBW7_1	448:455	LQSTPGRS	FBXW7	0.7016	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons