DegronMD

Uniprot ID: O60346

Source protein: PH domain leucine-rich repeat-containing protein phosphatase 1

Source gene: PHLPP1

Class: LIG_APCC_ABBA_1

Location: 1095:1100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5374

ASA_SCORE: 58.85

COIL: 0.8578

CONS_SCORE: 0.6007

DSS_SCORE: 0.0603

HELIX: 0.0218

FCONS_SCORE: 1.1598

RIG_SCORE: 0.885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1106Q	TCGA-18-3421	LUSC	TCGA	IEVFPE	LIG_APCC_ABBA_1	0.1667
p.V1088M	TCGA-2W-A8YY	CESC	TCGA	IEVFPE	LIG_APCC_ABBA_1	0.1389
p.V1088M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	IEVFPE	LIG_APCC_ABBA_1	0.1389
p.V1088M	SIDM01450	Gastric Carcinoma	GDSC	IEVFPE	LIG_APCC_ABBA_1	0.1389
p.E1100K	TCGA-AN-A046	BRCA	TCGA	IEVFPE	LIG_APCC_ABBA_1	0.7022
p.R1109W	DO49005	CESC	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.0833
p.G1093S	DO23374	LINC	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.2778
p.G1104R	DO229470	SKCA	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.2222
p.R1108C	DO43306	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.2222
p.D1090N	DO41644	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.1944
p.G1104V	DO42504	UCEC	ICGC	IEVFPE	LIG_APCC_ABBA_1	0.2222
p.H1086Y	SIDM01090	Colorectal Carcinoma	GDSC	IEVFPE	LIG_APCC_ABBA_1	0.0833
p.H1086Y	ACH-000943	Colon/Colorectal Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	0.0833
p.H1086Y	ACH-001786	Colon/Colorectal Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	0.0833
p.H1086Y	RKO	large_intestine	COSMIC	IEVFPE	LIG_APCC_ABBA_1	0.0833
p.T1087I	ACH-000899	Skin Cancer	CCLE	IEVFPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60346	PH domain leucine-rich repeat-containing protein phosphatase 1	LIG_APCC_ABBA_1	1095:1100	IEVFPE	APC,CDC20,FZR1	0.5374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons