DegronMD - Q8WYL5(SSH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E25G	TCGA-13-1488	OV	TCGA	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1389
p.E25G	DO29438	OV	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1389
p.S926C	TCGA-52-7810	LUSC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation altering degron motif	0.7541
p.S926C	TCGA-52-7810	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.7541
p.S926C	DO27381	LUSC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation altering degron motif	0.7541
p.S926C	DO27381	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation altering degron motif	0.7541
p.D472Y	TCGA-56-8629	LUSC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1111
p.D472Y	DO45451	LUSC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1111
p.R934Q	TCGA-58-A46N	LUSC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.1111
p.R934Q	TCGA-58-A46N	LUSC	TCGA	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.R934Q	TCGA-WC-A885	UVM	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.1111
p.R934Q	TCGA-WC-A885	UVM	TCGA	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.R934Q	DO45460	LUSC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.1111
p.R934Q	DO45460	LUSC	ICGC	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.R934W	TCGA-AX-A2HA	UCEC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.1111
p.R934W	TCGA-AX-A2HA	UCEC	TCGA	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.R934W	DO42504	UCEC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.1111
p.R934W	DO42504	UCEC	ICGC	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.1389
p.G477D	TCGA-BG-A222	UCEC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.25
p.G477D	DO42977	UCEC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.25
p.E482Q	TCGA-C5-A8XK	CESC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation altering degron motif	0.5633
p.E482Q	DO49904	CESC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation altering degron motif	0.5633
p.P488Q	TCGA-D3-A2JH	SKCM	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.P488Q	DO47263	SKCM	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.S970F	TCGA-D3-A2JK	SKCM	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation blocking phosphorylation signal	0.7222
p.S970F	DO37619	SKCM	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation blocking phosphorylation signal	0.7222
p.T968S	TCGA-D7-A4YT	STAD	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.6005
p.T968S	DO47723	STAD	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.6005
p.P488S	TCGA-DA-A1I5	SKCM	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.P488S	DO37447	SKCM	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.D497G	TCGA-DI-A1BU	UCEC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.0556
p.D497G	DO42023	UCEC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.0556
p.R961W	TCGA-EO-A22U	UCEC	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.8634
p.R961W	DO43755	UCEC	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.8634
p.M928I	TCGA-JW-A5VJ	CESC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.2778
p.M928I	TCGA-JW-A5VJ	CESC	TCGA	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.3056
p.M928I	DO49974	CESC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	919:926	Mutation rewiring degron network	0.2778
p.M928I	DO49974	CESC	ICGC	PTSSS	DEG_SPOP_SBC_1	923:927	Mutation rewiring degron network	0.3056
p.V969I	DO230312	COCA	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.3056
p.V969I	SIDM00969	Ovarian Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.3056
p.V969I	SIDM00710	Small Cell Lung Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.3056
p.P484L	DO222842	COCA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation altering degron motif	0.7582
p.T960S	DO233259	GACA	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation altering degron motif	0.6005
p.D27N	DO233634	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.A19V	DO233760	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.3056
p.S17L	DO233791	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.S17L	DO40884	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.S17L	DO43186	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.S17L	DO41644	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.S17L	DO41542	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.S17L	DO42753	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7667
p.Q491K	DO228948	LICA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.2222
p.S11R	DO229025	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation blocking phosphorylation signal	0.6944
p.D472E	DO229038	LICA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1111
p.H977Y	DO229177	LMS	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.0833
p.F479L	DO232761	PBCA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.P12A	DO51062	PRAD	ICGC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2778
p.R975C	SIDM00216	Colorectal Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1389
p.R975C	ACH-000989	Colon/Colorectal Cancer	CCLE	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1389
p.R975C	SNU-175	large intestine	COSMIC	TRLRLAGLT	DEG_APCC_DBOX_1	960:968	Mutation rewiring degron network	0.1389
p.D27Y	SIDM00467	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.D27Y	QIMR-WIL	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.P493S	SIDM00217	Colorectal Carcinoma	GDSC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1667
p.P493S	ACH-000999	Colon/Colorectal Cancer	CCLE	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1667
p.P493S	SNU-1040	large intestine	COSMIC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.1667
p.P488L	ACH-001566	Skin Cancer	CCLE	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.3056
p.R470H	HDQ-P1	breast	COSMIC	LPETPDGT	DEG_SCF_FBW7_1	480:487	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SSH1

UniProt ID: Q8WYL5

Entrez ID: 54434

Protein name: Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SSH1 in