DegronMD

Uniprot ID: Q8WYL5

Source protein: Protein phosphatase Slingshot homolog 1

Source gene: SSH1

Class: DEG_SCF_FBW7_1

Location: 480:487

E3 ligase: FBXW7

DEGRON score: 0.9736

ASA_SCORE: 79

COIL: 0.9406

CONS_SCORE: 0.2659

DSS_SCORE: 0.8581

HELIX: 0.0156

FCONS_SCORE: 0.9126

RIG_SCORE: 0.6013

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D472Y	TCGA-56-8629	LUSC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.1111
p.D472Y	DO45451	LUSC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.1111
p.G477D	TCGA-BG-A222	UCEC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.25
p.G477D	DO42977	UCEC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.25
p.E482Q	TCGA-C5-A8XK	CESC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.5633
p.E482Q	DO49904	CESC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.5633
p.P488Q	TCGA-D3-A2JH	SKCM	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.P488Q	DO47263	SKCM	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.P488S	TCGA-DA-A1I5	SKCM	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.P488S	DO37447	SKCM	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.D497G	TCGA-DI-A1BU	UCEC	TCGA	LPETPDGT	DEG_SCF_FBW7_1	0.0556
p.D497G	DO42023	UCEC	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.0556
p.P484L	DO222842	COCA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.7582
p.Q491K	DO228948	LICA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.2222
p.D472E	DO229038	LICA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.1111
p.F479L	DO232761	PBCA	ICGC	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.P493S	SIDM00217	Colorectal Carcinoma	GDSC	LPETPDGT	DEG_SCF_FBW7_1	0.1667
p.P493S	ACH-000999	Colon/Colorectal Cancer	CCLE	LPETPDGT	DEG_SCF_FBW7_1	0.1667
p.P493S	SNU-1040	large_intestine	COSMIC	LPETPDGT	DEG_SCF_FBW7_1	0.1667
p.P488L	ACH-001566	Skin Cancer	CCLE	LPETPDGT	DEG_SCF_FBW7_1	0.3056
p.R470H	HDQ-P1	breast	COSMIC	LPETPDGT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SCF_FBW7_1	480:487	LPETPDGT	FBXW7	0.9736	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons