DegronMD

Uniprot ID: Q8WYL5

Source protein: Protein phosphatase Slingshot homolog 1

Source gene: SSH1

Class: DEG_APCC_DBOX_1

Location: 960:968

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.961

ASA_SCORE: 84.3778

COIL: 0.4183

CONS_SCORE: 0.3747

DSS_SCORE: 0.3717

HELIX: 0.5729

FCONS_SCORE: 1.1302

RIG_SCORE: 0.8082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S970F	TCGA-D3-A2JK	SKCM	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	0.7222
p.S970F	DO37619	SKCM	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.7222
p.T968S	TCGA-D7-A4YT	STAD	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	0.6005
p.T968S	DO47723	STAD	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.6005
p.R961W	TCGA-EO-A22U	UCEC	TCGA	TRLRLAGLT	DEG_APCC_DBOX_1	0.8634
p.R961W	DO43755	UCEC	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.8634
p.V969I	DO230312	COCA	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.3056
p.V969I	SIDM00969	Ovarian Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	0.3056
p.V969I	SIDM00710	Small Cell Lung Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	0.3056
p.T960S	DO233259	GACA	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.6005
p.H977Y	DO229177	LMS	ICGC	TRLRLAGLT	DEG_APCC_DBOX_1	0.0833
p.R975C	SIDM00216	Colorectal Carcinoma	GDSC	TRLRLAGLT	DEG_APCC_DBOX_1	0.1389
p.R975C	ACH-000989	Colon/Colorectal Cancer	CCLE	TRLRLAGLT	DEG_APCC_DBOX_1	0.1389
p.R975C	SNU-175	large_intestine	COSMIC	TRLRLAGLT	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_APCC_DBOX_1	960:968	TRLRLAGLT	APC,CDC20,FZR1	0.961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons