DegronMD

Uniprot ID: Q8WYL5

Source protein: Protein phosphatase Slingshot homolog 1

Source gene: SSH1

Class: DEG_SCF_FBW7_1

Location: 919:926

E3 ligase: FBXW7

DEGRON score: 0.9596

ASA_SCORE: 72.8625

COIL: 0.681

CONS_SCORE: 0.3537

DSS_SCORE: 0.3075

HELIX: 0.0823

FCONS_SCORE: 1.1198

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S926C	TCGA-52-7810	LUSC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	0.7541
p.S926C	DO27381	LUSC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	0.7541
p.R934Q	TCGA-58-A46N	LUSC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	0.1111
p.R934Q	TCGA-WC-A885	UVM	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	0.1111
p.R934Q	DO45460	LUSC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	0.1111
p.R934W	TCGA-AX-A2HA	UCEC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	0.1111
p.R934W	DO42504	UCEC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	0.1111
p.M928I	TCGA-JW-A5VJ	CESC	TCGA	ICYTPTSS	DEG_SCF_FBW7_1	0.2778
p.M928I	DO49974	CESC	ICGC	ICYTPTSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYL5	Protein phosphatase Slingshot homolog 1	DEG_SCF_FBW7_1	919:926	ICYTPTSS	FBXW7	0.9596	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons