DegronMD - P35568(IRS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S681T	TCGA-25-1313	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.6005
p.S681T	DO28050	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.6005
p.S681C	TCGA-25-1313	OV	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7541
p.S681C	DO28050	OV	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7541
p.G611C	TCGA-43-2576	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1667
p.G611C	DO27005	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1667
p.S672C	TCGA-49-4514	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation blocking phosphorylation signal	0.5833
p.S672C	DO23818	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation blocking phosphorylation signal	0.5833
p.V689F	TCGA-50-5049	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1667
p.V689F	DO23705	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1667
p.W164C	TCGA-51-4079	LUSC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.7
p.W164C	DO26437	LUSC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.7
p.W164L	TCGA-51-4079	LUSC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.7015
p.W164L	DO26437	LUSC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.7015
p.K177N	TCGA-A5-A2K5	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation substituting flanking lysine	0.1944
p.K177N	TCGA-AJ-A3EK	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation substituting flanking lysine	0.1944
p.K177N	DO41584	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation substituting flanking lysine	0.1944
p.K177N	DO41379	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation substituting flanking lysine	0.1944
p.V154M	TCGA-A6-5659	COAD	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.1667
p.V154M	DO9860	COAD	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.1667
p.H607R	TCGA-A6-A566	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.2778
p.H607R	DO44092	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.2778
p.K161N	TCGA-AA-3947	COAD	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.5806
p.K161N	DO8192	COAD	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation altering degron motif	0.5806
p.P1047S	TCGA-AJ-A3EK	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.0556
p.P1047S	DO41584	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.0556
p.N178K	TCGA-AP-A051	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.0556
p.N178K	DO42673	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.0556
p.R594C	TCGA-AZ-6598	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	TCGA-D1-A103	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	DO10276	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	DO42312	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	SIDM00516	Melanoma	GDSC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	SIDM01879	Non-Cancerous	GDSC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R594C	ACH-002361	Non-Cancerous	CCLE	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.R600C	TCGA-DA-A95Z	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.3056
p.R600C	DO219481	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.3056
p.E1023K	TCGA-FD-A6TB	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.0556
p.E1023K	DO51879	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.0556
p.L592V	TCGA-IM-A420	THCA	TCGA	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.0833
p.L592V	DO39516	THCA	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.0833
p.S681N	TCGA-L5-A8NI	ESCA	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7069
p.P690H	TCGA-N5-A4R8	UCS	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1389
p.G676E	TCGA-W5-AA39	CHOL	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.25
p.I675V	TCGA-ZF-AA4V	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.I675V	DO219087	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.2222
p.P1044T	DO4155	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.1389
p.R600H	DO233079	GACA	ICGC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.3056
p.K171N	DO233882	GACA	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation substituting flanking lysine	0.3611
p.G678V	DO230968	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.3056
p.G678V	DO224621	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.3056
p.S691F	DO220853	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1111
p.D674A	DO51474	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1944
p.A159T	DO232761	PBCA	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.3056
p.R594H	SIDM02034	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.1389
p.L173P	SIDM01090	Colorectal Carcinoma	GDSC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.1944
p.L173P	ACH-000943	Colon/Colorectal Cancer	CCLE	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.1944
p.L173P	RKO	large intestine	COSMIC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.1944
p.A1029S	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.2222
p.A1029S	ACH-001233	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.2222
p.A1029S	VMRC-LCD	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.2222
p.G597E	SIDM00335	Endometrial Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.2222
p.G597E	MFE-280	endometrium	COSMIC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.2222
p.V689I	SIDM00493	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1667
p.V689I	NCI-H292	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation rewiring degron network	0.1667
p.P679R	SIDM01157	Other Solid Cancers	GDSC	PSSSS	DEG_SPOP_SBC_1	679:683	Mutation altering degron motif	0.7512
p.P156S	SIDM00217	Colorectal Carcinoma	GDSC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.2222
p.P156S	ACH-000999	Colon/Colorectal Cancer	CCLE	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.2222
p.P156S	SNU-1040	large intestine	COSMIC	FKEVWQVIL	DEG_MDM2_SWIB_1	160:168	Mutation rewiring degron network	0.2222
p.P614A	SIDM01387	Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.0833
p.P614A	ACH-000921	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	601:605	Mutation rewiring degron network	0.0833
p.A1032T	ACH-001029	Bone Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.3056
p.A1032T	ACH-001034	Bone Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.3056
p.M1031T	ACH-001523	Skin Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	1033:1037	Mutation rewiring degron network	0.2778

Kaplan plot for IRS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRS1

UniProt ID: P35568

Entrez ID: 3667

Protein name: Insulin receptor substrate 1 (IRS-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRS1 in