DegronMD

Uniprot ID: P35568

Source protein: Insulin receptor substrate 1

Source gene: IRS1

Class: DEG_SPOP_SBC_1

Location: 601:605

E3 ligase: SPOP

DEGRON score: 0.6597

ASA_SCORE: 82.98

COIL: 0.8946

CONS_SCORE: 0.399

DSS_SCORE: 0.7304

HELIX: 0.0794

FCONS_SCORE: 0.8627

RIG_SCORE: 0.5606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G611C	TCGA-43-2576	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1667
p.G611C	DO27005	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1667
p.H607R	TCGA-A6-A566	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.2778
p.H607R	DO44092	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.2778
p.R594C	TCGA-AZ-6598	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	TCGA-D1-A103	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	DO10276	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	DO42312	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	SIDM00516	Melanoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	SIDM01879	Non-Cancerous	GDSC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R594C	ACH-002361	Non-Cancerous	CCLE	PDSST	DEG_SPOP_SBC_1	0.1389
p.R600C	TCGA-DA-A95Z	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.3056
p.R600C	DO219481	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.3056
p.L592V	TCGA-IM-A420	THCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.0833
p.L592V	DO39516	THCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0833
p.R600H	DO233079	GACA	ICGC	PDSST	DEG_SPOP_SBC_1	0.3056
p.R594H	SIDM02034	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1389
p.G597E	SIDM00335	Endometrial Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.2222
p.G597E	MFE-280	endometrium	COSMIC	PDSST	DEG_SPOP_SBC_1	0.2222
p.P614A	SIDM01387	Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.0833
p.P614A	ACH-000921	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons