DegronMD - Q1X8D7(LRRC36)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A372P	TCGA-49-AAR0	LUAD	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.S545C	TCGA-66-2785	LUSC	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1111
p.A372T	TCGA-69-7980	LUAD	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.A372T	TCGA-E6-A1LX	UCEC	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.D378Y	TCGA-A5-A1OF	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1111
p.A520V	TCGA-AB-2826	LAML	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.0833
p.N356Y	TCGA-AP-A059	UCEC	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation altering degron motif	0.7059
p.S382F	TCGA-CA-6718	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.2222
p.R350K	TCGA-DU-A7T6	LGG	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1667
p.L347I	TCGA-EO-A3B0	UCEC	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.0833
p.K355N	TCGA-EY-A1GD	UCEC	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.3056
p.P386S	TCGA-NK-A7XE	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.6752
p.L546I	TCGA-VQ-A8E3	STAD	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.0833
p.H374R	TCGA-ZF-AA52	BLCA	TCGA	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.0556
p.M534I	DO31769	OV	ICGC	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation altering degron motif	0.7618
p.P364H	SIDM00683	Prostate Carcinoma	GDSC	NYQEYSIKP	CBL_PTK	356:364	Mutation altering degron motif	0.7694
p.P364H	LNCaP-Clone-FGC	prostate	COSMIC	NYQEYSIKP	CBL_PTK	356:364	Mutation altering degron motif	0.7694
p.G542C	SIDM00127	Oral Cavity Carcinoma	GDSC	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1944
p.G542C	ACH-002250	Head and Neck Cancer	CCLE	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1944
p.G542C	JHU-022	upper aerodigestive tract	COSMIC	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.1944
p.S346L	ACH-000008	Skin Cancer	CCLE	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.0556
p.S346L	A101D	skin	COSMIC	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.0556
p.K381T	ACH-000432	Leukemia	CCLE	PDSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1944
p.K381T	ACH-000531	Non-Cancerous	CCLE	PDSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1944
p.K381T	BV-173	haematopoietic and lymphoid tissue	COSMIC	PDSST	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.1944
p.S348I	ACH-000997	Colon/Colorectal Cancer	CCLE	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.S348I	ACH-001061	Colon/Colorectal Cancer	CCLE	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.S348I	HCT-15	large intestine	COSMIC	NYQEYSIKP	CBL_PTK	356:364	Mutation rewiring degron network	0.1111
p.L361F	ACH-001550	Skin Cancer	CCLE	NYQEYSIKP	CBL_PTK	356:364	Mutation altering degron motif	0.6981
p.L361F	MCC13	skin	COSMIC	NYQEYSIKP	CBL_PTK	356:364	Mutation altering degron motif	0.6981
p.C538S	MDA-MB-453	breast	COSMIC	LRQLLELVD	DEG_APCC_DBOX_1	529:537	Mutation rewiring degron network	0.3056
p.H387P	JHH-1	liver	COSMIC	PDSST	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7694
p.P395L	NCI-H661	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	386:390	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC36

UniProt ID: Q1X8D7

Entrez ID: 55282

Protein name: Leucine-rich repeat-containing protein 36 (ROR gamma-binding protein 70)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC36 in