DegronMD

Uniprot ID: Q1X8D7

Source protein: Leucine-rich repeat-containing protein 36

Source gene: LRRC36

Class: DEG_SPOP_SBC_1

Location: 386:390

E3 ligase: SPOP

DEGRON score: 0.5318

ASA_SCORE: 86.34

COIL: 0.8638

CONS_SCORE: 0.4374

DSS_SCORE: 0.3297

HELIX: 0.1086

FCONS_SCORE: 1.0198

RIG_SCORE: 0.6675

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D378Y	TCGA-A5-A1OF	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.S382F	TCGA-CA-6718	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.2222
p.P386S	TCGA-NK-A7XE	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.6752
p.K381T	ACH-000432	Leukemia	CCLE	PDSST	DEG_SPOP_SBC_1	0.1944
p.K381T	ACH-000531	Non-Cancerous	CCLE	PDSST	DEG_SPOP_SBC_1	0.1944
p.K381T	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1944
p.H387P	JHH-1	liver	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7694
p.P395L	NCI-H661	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons