DegronMD - Q9H9S0(NANOG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M58I	TCGA-32-1991	GBM	TCGA	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58I	DO12754	GBM	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58I	SIDM00150	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58I	ACH-000969	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58I	KM12	large intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.S68Y	TCGA-BS-A0UJ	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.8231
p.S68Y	DO42745	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.8231
p.A80V	TCGA-FD-A43X	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.A80V	DO44067	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.T78I	TCGA-NI-A4U2	LIHC	TCGA	PDSST	DEG_SPOP_SBC_1	66:70	Mutation blocking phosphorylation signal	0.5556
p.T78I	DO48589	LIHC	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation blocking phosphorylation signal	0.5556
p.T70P	DO231953	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.8142
p.P66H	DO228955	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7694
p.P66H	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7694
p.P66H	ACH-000510	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7694
p.P66H	NCI-H1299	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7694
p.A80S	DO229027	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0556
p.D59N	DO222653	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.D59N	DO229456	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1389
p.P66T	SIDM01156	Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7031
p.P66T	ACH-000890	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7031
p.P66T	SW1271	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7031
p.M58V	SIDM00487	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58V	ACH-000963	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.M58V	CCK-81	large intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1111
p.P66L	SIDM01587	Bladder Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7582

Kaplan plot for NANOG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NANOG

UniProt ID: Q9H9S0

Entrez ID: 79923

Protein name: Homeobox protein NANOG (Homeobox transcription factor Nanog) (hNanog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NANOG in