DegronMD

Uniprot ID: Q9H9S0

Source protein: Homeobox protein NANOG

Source gene: NANOG

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.9889

ASA_SCORE: 88.56

COIL: 0.9274

CONS_SCORE: 0.9304

DSS_SCORE: 0.7497

HELIX: 0.063

FCONS_SCORE: 1.2748

RIG_SCORE: 0.5462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M58I	TCGA-32-1991	GBM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58I	DO12754	GBM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58I	SIDM00150	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58I	ACH-000969	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58I	KM12	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1111
p.S68Y	TCGA-BS-A0UJ	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.8231
p.S68Y	DO42745	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.8231
p.A80V	TCGA-FD-A43X	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.0556
p.A80V	DO44067	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0556
p.T78I	TCGA-NI-A4U2	LIHC	TCGA	PDSST	DEG_SPOP_SBC_1	0.5556
p.T78I	DO48589	LIHC	ICGC	PDSST	DEG_SPOP_SBC_1	0.5556
p.T70P	DO231953	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.8142
p.P66H	DO228955	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.7694
p.P66H	SIDM00649	Non-Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7694
p.P66H	ACH-000510	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.7694
p.P66H	NCI-H1299	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7694
p.A80S	DO229027	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0556
p.D59N	DO222653	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.D59N	DO229456	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.P66T	SIDM01156	Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7031
p.P66T	ACH-000890	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.7031
p.P66T	SW1271	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7031
p.M58V	SIDM00487	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58V	ACH-000963	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.1111
p.M58V	CCK-81	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1111
p.P66L	SIDM01587	Bladder Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons