DegronMD

Uniprot ID: O14994

Source protein: Synapsin-3

Source gene: SYN3

Class: DEG_SPOP_SBC_1

Location: 28:32

E3 ligase: SPOP

DEGRON score: 0.9249

ASA_SCORE: 91.02

COIL: 0.9734

CONS_SCORE: 0.3247

DSS_SCORE: 0.693

HELIX: 0.0158

FCONS_SCORE: 0.8777

RIG_SCORE: 0.5714

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A39T	TCGA-06-5416	GBM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.A39T	TCGA-EO-A22R	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.A39T	DO10880	GBM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.A39T	DO42713	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.Q26E	TCGA-69-7980	LUAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.2778
p.Q26E	DO23678	LUAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.2778
p.M40T	TCGA-85-A5B5	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.M40T	DO50102	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.R27P	TCGA-DK-AA6U	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.3056
p.R27P	DO219008	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.3056
p.G20D	TCGA-E6-A1LX	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.G20D	DO41020	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.M22I	TCGA-GV-A3JX	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.1667
p.M22I	DO448	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1667
p.R27H	TCGA-IB-7651	PAAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.3056
p.R27H	DO46657	PAAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.3056
p.S37F	TCGA-YG-AA3N	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1944
p.S37F	DO51298	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.D24E	DO228948	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.2222
p.R27S	DO229027	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.3056
p.S37P	DO218842	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.S37P	DO218890	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.R42G	SIDM00664	Pancreatic Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.0556
p.S30C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7541
p.S30C	ACH-000945	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.7541
p.S30C	NCI-H650	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7541
p.T23M	SIDM00844	Burkitt's Lymphoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1944
p.T23M	SIDM01664	Prostate Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1944
p.M40R	ACH-002186	Pancreatic Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.1111
p.M40R	PL4	pancreas	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1111
p.D31G	EN	endometrium	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7198
p.R37C	SNU-175	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSST

Degron related mutations and impact score

Drug responses associated with SYN3 mutations

All proteins holding degron of PDSST