DegronMD - Q9NYZ3(GTSE1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L312P	TCGA-5M-AAT6	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation blocking phosphorylation signal	0.5833
p.L312P	DO223703	COAD	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation blocking phosphorylation signal	0.5833
p.S476Y	TCGA-AG-A002	READ	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0556
p.S476Y	TCGA-DU-6392	LGG	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0556
p.S476Y	DO22237	LGG	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0556
p.A704T	TCGA-AY-6197	COAD	TCGA	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.1944
p.A704T	DO9956	COAD	ICGC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.1944
p.A303V	TCGA-B5-A3FC	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6936
p.A303V	DO41871	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6936
p.P87R	TCGA-B6-A0I1	BRCA	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.P87R	DO4138	BRCA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.D453V	TCGA-BH-A0BC	BRCA	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0833
p.D453V	DO4817	BRCA	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0833
p.P80S	TCGA-BH-A2L8	BRCA	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.P80S	DO44242	BRCA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.S454F	TCGA-C5-A1MH	CESC	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1111
p.S454F	DO48982	CESC	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1111
p.G300V	TCGA-CJ-5686	KIRC	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.3056
p.G300V	DO19490	KIRC	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.3056
p.P708L	TCGA-D3-A2JN	SKCM	TCGA	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.3056
p.P708L	DO47590	SKCM	ICGC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.3056
p.P307L	TCGA-EB-A3XC	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778
p.P307L	DO37579	SKCM	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778
p.F98L	TCGA-EE-A3J5	SKCM	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.F98L	DO47331	SKCM	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.P466L	TCGA-FS-A1Z3	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7582
p.P466L	DO37635	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7582
p.L456I	TCGA-G2-AA3D	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1667
p.L456I	DO51884	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1667
p.E85K	TCGA-G7-A8LB	KIRP	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.E85K	DO51553	KIRP	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.V99M	TCGA-QC-A7B5	SARC	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1944
p.V99M	DO220239	SARC	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1944
p.S717I	TCGA-X6-A7WA	SARC	TCGA	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.2222
p.S717I	DO220312	SARC	ICGC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.2222
p.D453Y	DO233115	GACA	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.0833
p.L723V	DO229505	LAML	ICGC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00961	Ewing's Sarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00353	Other Sarcomas	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00570	Gastric Carcinoma	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00569	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM01181	Hepatocellular Carcinoma	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00397	Acute Myeloid Leukemia	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.L723V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.0556
p.K97N	DO229015	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.25
p.S91I	DO229027	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation altering degron motif	0.7341
p.V99L	DO229032	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1944
p.S91R	DO48719	LIRI	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation altering degron motif	0.7427
p.P80Q	DO230934	LUSC	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.P80Q	DO224581	LUSC	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.P80L	SIDM00403	T-Lymphoblastic Leukemia	GDSC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.P80L	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.0833
p.P305S	SIDM01175	Other Sarcomas	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.P305S	ACH-002309	Sarcoma	CCLE	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.P305S	SW684	soft tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.G298S	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.G298S	ACH-002256	Leukemia	CCLE	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.G298S	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.25
p.E85D	SIDM00924	Other Solid Cancers	GDSC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.E85D	ACH-000867	Lung Cancer	CCLE	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.E85D	ChaGo-K-1	lung	COSMIC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2222
p.G294R	SIDM00192	Colorectal Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation substituting flanking lysine	0.25
p.G294R	SIDM01658	Unknown	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation substituting flanking lysine	0.25
p.R302W	SIDM01617	Endometrial Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.8634
p.R302W	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.8634
p.Q469H	ACH-001521	Skin Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.25
p.P473S	ACH-002396	Bone Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1389
p.P473S	Sarc9371	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation rewiring degron network	0.1389
p.V101M	ACH-002693	Sarcoma	CCLE	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTSE1

UniProt ID: Q9NYZ3

Entrez ID: 51512

Protein name: G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTSE1 in