DegronMD - Q9NYZ3(GTSE1)

FUNCTION: May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

GO - Biological processes (BP): DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [GO:0006977]; microtubule-based process [GO:0007017]

GO - Molecular function (MF): microtubule binding [GO:0008017]

GO - Cellular component (CC): cytoplasmic microtubule [GO:0005881]; cytosol [GO:0005829]; membrane [GO:0016020]; microtubule cytoskeleton [GO:0015630]; nucleoplasm [GO:0005654]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R302W	SIDM01617	Endometrial Carcinoma	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.8634
p.R302W	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.8634
p.P466L	TCGA-FS-A1Z3	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7582
p.P466L	DO37635	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	462:466	Mutation altering degron motif	0.7582
p.S91R	DO48719	LIRI	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation altering degron motif	0.7427
p.S91I	DO229027	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation altering degron motif	0.7341
p.A303V	TCGA-B5-A3FC	UCEC	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6936
p.A303V	DO41871	UCEC	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6936
p.P305S	SIDM01175	Other Sarcomas	GDSC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.P305S	ACH-002309	Sarcoma	CCLE	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.P305S	SW684	soft tissue	COSMIC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation altering degron motif	0.6752
p.L312P	TCGA-5M-AAT6	COAD	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation blocking phosphorylation signal	0.5833
p.L312P	DO223703	COAD	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation blocking phosphorylation signal	0.5833
p.G300V	TCGA-CJ-5686	KIRC	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.3056
p.G300V	DO19490	KIRC	ICGC	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.3056
p.P708L	TCGA-D3-A2JN	SKCM	TCGA	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.3056
p.P708L	DO47590	SKCM	ICGC	DKENV	DEG_APCC_KENBOX_2	709:713	Mutation rewiring degron network	0.3056
p.P87R	TCGA-B6-A0I1	BRCA	TCGA	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.P87R	DO4138	BRCA	ICGC	LALHIE	LIG_APCC_ABBA_1	89:94	Mutation rewiring degron network	0.2778
p.P307L	TCGA-EB-A3XC	SKCM	TCGA	PGSTS	DEG_SPOP_SBC_1	301:305	Mutation rewiring degron network	0.2778

Showing 1 to 20 of 69 entries

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Kaplan plot for GTSE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GTSE1

UniProt ID: Q9NYZ3

Entrez ID: 51512

Protein name: G2 and S phase-expressed protein 1 (GTSE-1) (Protein B99 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GTSE1 in