DegronMD

Uniprot ID: Q9NYZ3

Source protein: G2 and S phase-expressed protein 1

Source gene: GTSE1

Class: DEG_APCC_KENBOX_2

Location: 709:713

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9319

ASA_SCORE: 94.54

COIL: 0.851

CONS_SCORE: 0.6248

DSS_SCORE: 0.448

HELIX: 0.0864

FCONS_SCORE: 1.1333

RIG_SCORE: 0.7162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A704T	TCGA-AY-6197	COAD	TCGA	DKENV	DEG_APCC_KENBOX_2	0.1944
p.A704T	DO9956	COAD	ICGC	DKENV	DEG_APCC_KENBOX_2	0.1944
p.P708L	TCGA-D3-A2JN	SKCM	TCGA	DKENV	DEG_APCC_KENBOX_2	0.3056
p.P708L	DO47590	SKCM	ICGC	DKENV	DEG_APCC_KENBOX_2	0.3056
p.S717I	TCGA-X6-A7WA	SARC	TCGA	DKENV	DEG_APCC_KENBOX_2	0.2222
p.S717I	DO220312	SARC	ICGC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.L723V	DO229505	LAML	ICGC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00961	Ewing's Sarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00353	Other Sarcomas	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00570	Gastric Carcinoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00569	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM01181	Hepatocellular Carcinoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00397	Acute Myeloid Leukemia	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.L723V	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	624:628	DKENV	APC,CDC20,FZR1	0.9776	More...
P21359	Neurofibromin	DEG_APCC_KENBOX_2	2795:2799	DKENV	APC,CDC20,FZR1	0.8116	More...
Q8IUH5	Palmitoyltransferase ZDHHC17	DEG_APCC_KENBOX_2	87:91	DKENV	APC,CDC20,FZR1	0.5783	More...
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_APCC_KENBOX_2	299:303	DKENV	APC,CDC20,FZR1	0.8406	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_APCC_KENBOX_2	709:713	DKENV	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons