DegronMD

Uniprot ID: Q8IUH5

Source protein: Palmitoyltransferase ZDHHC17

Source gene: ZDHHC17

Class: DEG_APCC_KENBOX_2

Location: 87:91

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5783

ASA_SCORE: 78.78

COIL: 0.9364

CONS_SCORE: 0.5231

DSS_SCORE: 0.1151

HELIX: 0.0122

FCONS_SCORE: 1.3815

RIG_SCORE: 0.8455

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W96C	TCGA-2Y-A9H8	LIHC	TCGA	DKENV	DEG_APCC_KENBOX_2	0.1944
p.R84W	TCGA-A5-A0G2	UCEC	TCGA	DKENV	DEG_APCC_KENBOX_2	0.25
p.R84Q	TCGA-A8-A08B	BRCA	TCGA	DKENV	DEG_APCC_KENBOX_2	0.25
p.R84Q	SIDM00493	Other Solid Cancers	GDSC	DKENV	DEG_APCC_KENBOX_2	0.25
p.V83A	TCGA-AA-3672	COAD	TCGA	DKENV	DEG_APCC_KENBOX_2	0.2222
p.H86P	DO8264	COAD	ICGC	DKENV	DEG_APCC_KENBOX_2	0.3056
p.W80L	DO229037	LICA	ICGC	DKENV	DEG_APCC_KENBOX_2	0.1389
p.H86R	DO223282	UCEC	ICGC	DKENV	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	624:628	DKENV	APC,CDC20,FZR1	0.9776	More...
P21359	Neurofibromin	DEG_APCC_KENBOX_2	2795:2799	DKENV	APC,CDC20,FZR1	0.8116	More...
Q8IUH5	Palmitoyltransferase ZDHHC17	DEG_APCC_KENBOX_2	87:91	DKENV	APC,CDC20,FZR1	0.5783	More...
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_APCC_KENBOX_2	299:303	DKENV	APC,CDC20,FZR1	0.8406	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_APCC_KENBOX_2	709:713	DKENV	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons