DegronMD

Uniprot ID: O43683

Source protein: Mitotic checkpoint serine/threonine-protein kinase BUB1

Source gene: BUB1

Class: DEG_APCC_KENBOX_2

Location: 624:628

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9776

ASA_SCORE: 84.62

COIL: 0.3308

CONS_SCORE: 0.3238

DSS_SCORE: 0.3264

HELIX: 0.6448

FCONS_SCORE: 1.2011

RIG_SCORE: 0.805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V619A	TCGA-AA-A01P	COAD	TCGA	DKENV	DEG_APCC_KENBOX_2	0.1944
p.V619A	DO8642	COAD	ICGC	DKENV	DEG_APCC_KENBOX_2	0.1944
p.V628M	TCGA-AP-A1DK	UCEC	TCGA	DKENV	DEG_APCC_KENBOX_2	0.6097
p.V628M	DO42033	UCEC	ICGC	DKENV	DEG_APCC_KENBOX_2	0.6097
p.M625K	DO22804	LICA	ICGC	DKENV	DEG_APCC_KENBOX_2	0.8062
p.H620P	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	624:628	DKENV	APC,CDC20,FZR1	0.9776	More...
P21359	Neurofibromin	DEG_APCC_KENBOX_2	2795:2799	DKENV	APC,CDC20,FZR1	0.8116	More...
Q8IUH5	Palmitoyltransferase ZDHHC17	DEG_APCC_KENBOX_2	87:91	DKENV	APC,CDC20,FZR1	0.5783	More...
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_APCC_KENBOX_2	299:303	DKENV	APC,CDC20,FZR1	0.8406	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_APCC_KENBOX_2	709:713	DKENV	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons