DegronMD - P21359(NF1)

GO - Biological processes (BP): actin cytoskeleton organization [GO:0030036]; adrenal gland development [GO:0030325]; amygdala development [GO:0021764]; artery morphogenesis [GO:0048844]; brain development [GO:0007420]; camera-type eye morphogenesis [GO:0048593]; cell communication [GO:0007154]; cellular response to heat [GO:0034605]; cerebral cortex development [GO:0021987]; cognition [GO:0050890]; collagen fibril organization [GO:0030199]; extracellular matrix organization [GO:0030198]; extrinsic apoptotic signaling pathway via death domain receptors [GO:0008625]; forebrain astrocyte development [GO:0021897]; forebrain morphogenesis [GO:0048853]; gamma-aminobutyric acid secretion, neurotransmission [GO:0061534]; glutamate secretion, neurotransmission [GO:0061535]; hair follicle maturation [GO:0048820]; heart development [GO:0007507]; liver development [GO:0001889]; MAPK cascade [GO:0000165]; metanephros development [GO:0001656]; myelination in peripheral nervous system [GO:0022011]; negative regulation of angiogenesis [GO:0016525]; negative regulation of astrocyte differentiation [GO:0048712]; negative regulation of cell-matrix adhesion [GO:0001953]; negative regulation of cell migration [GO:0030336]; negative regulation of endothelial cell proliferation [GO:0001937]; negative regulation of fibroblast proliferation [GO:0048147]; negative regulation of MAPK cascade [GO:0043409]; negative regulation of MAP kinase activity [GO:0043407]; negative regulation of neuroblast proliferation [GO:0007406]; negative regulation of neurotransmitter secretion [GO:0046929]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of osteoclast differentiation [GO:0045671]; negative regulation of protein import into nucleus [GO:0042308]; negative regulation of protein kinase activity [GO:0006469]; negative regulation of Rac protein signal transduction [GO:0035021]; neural tube development [GO:0021915]; observational learning [GO:0098597]; osteoblast differentiation [GO:0001649]; peripheral nervous system development [GO:0007422]; phosphatidylinositol 3-kinase signaling [GO:0014065]; pigmentation [GO:0043473]; positive regulation of adenylate cyclase activity [GO:0045762]; positive regulation of apoptotic process [GO:0043065]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [GO:2001241]; positive regulation of GTPase activity [GO:0043547]; positive regulation of neuron apoptotic process [GO:0043525]; Ras protein signal transduction [GO:0007265]; regulation of angiogenesis [GO:0045765]; regulation of blood vessel endothelial cell migration [GO:0043535]; regulation of bone resorption [GO:0045124]; regulation of cell-matrix adhesion [GO:0001952]; regulation of gene expression [GO:0010468]; regulation of glial cell differentiation [GO:0045685]; regulation of GTPase activity [GO:0043087]; regulation of long-term neuronal synaptic plasticity [GO:0048169]; regulation of long-term synaptic potentiation [GO:1900271]; regulation of synaptic transmission, GABAergic [GO:0032228]; response to hypoxia [GO:0001666]; Schwann cell development [GO:0014044]; skeletal muscle tissue development [GO:0007519]; smooth muscle tissue development [GO:0048745]; spinal cord development [GO:0021510]; sympathetic nervous system development [GO:0048485]; visual learning [GO:0008542]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V2799I	TCGA-NF-A5CP	UCS	TCGA	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation altering degron motif	0.5965
p.A2786T	DO230336	COCA	ICGC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.0833
p.G2806C	DO228976	LICA	ICGC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.1389
p.P2803T	SIDM00584	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	SIDM00281	Other Solid Cancers	GDSC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	SIDM00569	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	ACH-002100	Skin Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	ACH-002142	Bone Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	ACH-002178	Bone Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	NY	bone	COSMIC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	DJM-1	skin	COSMIC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.P2803T	HuO-3N1	bone	COSMIC	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.2222
p.T2805I	ACH-000985	Colon/Colorectal Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	2795:2799	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NF1

UniProt ID: P21359

Entrez ID: 4763

Protein name: Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NF1 in