DegronMD

Uniprot ID: P21359

Source protein: Neurofibromin

Source gene: NF1

Class: DEG_APCC_KENBOX_2

Location: 2795:2799

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8116

ASA_SCORE: 85.58

COIL: 0.686

CONS_SCORE: 0.2129

DSS_SCORE: 0.6563

HELIX: 0.2334

FCONS_SCORE: 1.0176

RIG_SCORE: 0.6781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V2799I	TCGA-NF-A5CP	UCS	TCGA	DKENV	DEG_APCC_KENBOX_2	0.5965
p.A2786T	DO230336	COCA	ICGC	DKENV	DEG_APCC_KENBOX_2	0.0833
p.G2806C	DO228976	LICA	ICGC	DKENV	DEG_APCC_KENBOX_2	0.1389
p.P2803T	SIDM00584	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	SIDM00281	Other Solid Cancers	GDSC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	SIDM00569	Osteosarcoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	ACH-002100	Skin Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	ACH-002142	Bone Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	ACH-002178	Bone Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	NY	bone	COSMIC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	DJM-1	skin	COSMIC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P2803T	HuO-3N1	bone	COSMIC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.T2805I	ACH-000985	Colon/Colorectal Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	624:628	DKENV	APC,CDC20,FZR1	0.9776	More...
P21359	Neurofibromin	DEG_APCC_KENBOX_2	2795:2799	DKENV	APC,CDC20,FZR1	0.8116	More...
Q8IUH5	Palmitoyltransferase ZDHHC17	DEG_APCC_KENBOX_2	87:91	DKENV	APC,CDC20,FZR1	0.5783	More...
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_APCC_KENBOX_2	299:303	DKENV	APC,CDC20,FZR1	0.8406	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_APCC_KENBOX_2	709:713	DKENV	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons