DegronMD - Q9BY12(SCAPER)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S237L	TCGA-13-0807	OV	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.2778
p.S237L	DO28206	OV	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.2778
p.A242T	TCGA-A5-A0G2	UCEC	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.6028
p.A242T	TCGA-BA-6872	HNSC	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.6028
p.A242T	DO14236	HNSC	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.6028
p.A242T	DO41235	UCEC	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.6028
p.A242V	TCGA-AH-6897	READ	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.5825
p.A242V	DO36773	READ	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation altering degron motif	0.5825
p.P307R	TCGA-E2-A109	BRCA	TCGA	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation rewiring degron network	0.2222
p.P307R	DO4766	BRCA	ICGC	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation rewiring degron network	0.2222
p.K313R	TCGA-F5-6814	READ	TCGA	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation blocking ubiquitination signal	0.5
p.K313R	DO36556	READ	ICGC	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation blocking ubiquitination signal	0.5
p.S254L	TCGA-VQ-A8PE	STAD	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0556
p.S254L	DO51769	STAD	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0556
p.H230Y	TCGA-W3-AA1R	SKCM	TCGA	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.H230Y	DO51275	SKCM	ICGC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.V303I	DO46761	PAEN	ICGC	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation altering degron motif	0.5965
p.H230R	SIDM00994	T-Lymphoblastic Leukemia	GDSC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.H230R	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.T289A	SIDM00082	Melanoma	GDSC	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation rewiring degron network	0.0556
p.T289A	ACH-001190	Skin Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation rewiring degron network	0.0556
p.T289A	SK-MEL-2	skin	COSMIC	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation rewiring degron network	0.0556
p.S298I	ACH-000791	Lung Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	299:303	Mutation blocking phosphorylation signal	0.75
p.M230I	NCI-H1581	lung	COSMIC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833
p.M230K	NCI-H1581	lung	COSMIC	ITPAQS	DEG_SCF_FBW7_1	239:244	Mutation rewiring degron network	0.0833

Kaplan plot for SCAPER in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAPER

UniProt ID: Q9BY12

Entrez ID: 49855

Protein name: S phase cyclin A-associated protein in the endoplasmic reticulum (S phase cyclin A-associated protein in the ER) (Zinc finger protein 291)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCAPER in