DegronMD

Uniprot ID: Q9BY12

Source protein: S phase cyclin A-associated protein in the endoplasmic reticulum

Source gene: SCAPER

Class: DEG_SCF_FBW7_1

Location: 239:244

E3 ligase: FBXW7

DEGRON score: 0.6777

ASA_SCORE: 92.0667

COIL: 0.9032

CONS_SCORE: 0.3277

DSS_SCORE: 0.6397

HELIX: 0.0567

FCONS_SCORE: 1.0373

RIG_SCORE: 0.674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S237L	TCGA-13-0807	OV	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.2778
p.S237L	DO28206	OV	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.2778
p.A242T	TCGA-A5-A0G2	UCEC	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.6028
p.A242T	TCGA-BA-6872	HNSC	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.6028
p.A242T	DO14236	HNSC	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.6028
p.A242T	DO41235	UCEC	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.6028
p.A242V	TCGA-AH-6897	READ	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.5825
p.A242V	DO36773	READ	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.5825
p.S254L	TCGA-VQ-A8PE	STAD	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.0556
p.S254L	DO51769	STAD	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.0556
p.H230Y	TCGA-W3-AA1R	SKCM	TCGA	ITPAQS	DEG_SCF_FBW7_1	0.0833
p.H230Y	DO51275	SKCM	ICGC	ITPAQS	DEG_SCF_FBW7_1	0.0833
p.H230R	SIDM00994	T-Lymphoblastic Leukemia	GDSC	ITPAQS	DEG_SCF_FBW7_1	0.0833
p.H230R	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	ITPAQS	DEG_SCF_FBW7_1	0.0833
p.M230I	NCI-H1581	lung	COSMIC	ITPAQS	DEG_SCF_FBW7_1	0.0833
p.M230K	NCI-H1581	lung	COSMIC	ITPAQS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_SCF_FBW7_1	239:244	ITPAQS	FBXW7	0.6777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons