DegronMD

Uniprot ID: Q9BY12

Source protein: S phase cyclin A-associated protein in the endoplasmic reticulum

Source gene: SCAPER

Class: DEG_APCC_KENBOX_2

Location: 299:303

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8406

ASA_SCORE: 104.84

COIL: 0.6764

CONS_SCORE: 0.3286

DSS_SCORE: 0.5654

HELIX: 0.291

FCONS_SCORE: 0.9482

RIG_SCORE: 0.7634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P307R	TCGA-E2-A109	BRCA	TCGA	DKENV	DEG_APCC_KENBOX_2	0.2222
p.P307R	DO4766	BRCA	ICGC	DKENV	DEG_APCC_KENBOX_2	0.2222
p.K313R	TCGA-F5-6814	READ	TCGA	DKENV	DEG_APCC_KENBOX_2	0.5
p.K313R	DO36556	READ	ICGC	DKENV	DEG_APCC_KENBOX_2	0.5
p.V303I	DO46761	PAEN	ICGC	DKENV	DEG_APCC_KENBOX_2	0.5965
p.T289A	SIDM00082	Melanoma	GDSC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.T289A	ACH-001190	Skin Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.0556
p.T289A	SK-MEL-2	skin	COSMIC	DKENV	DEG_APCC_KENBOX_2	0.0556
p.S298I	ACH-000791	Lung Cancer	CCLE	DKENV	DEG_APCC_KENBOX_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43683	Mitotic checkpoint serine/threonine-protein kinase BUB1	DEG_APCC_KENBOX_2	624:628	DKENV	APC,CDC20,FZR1	0.9776	More...
P21359	Neurofibromin	DEG_APCC_KENBOX_2	2795:2799	DKENV	APC,CDC20,FZR1	0.8116	More...
Q8IUH5	Palmitoyltransferase ZDHHC17	DEG_APCC_KENBOX_2	87:91	DKENV	APC,CDC20,FZR1	0.5783	More...
Q9BY12	S phase cyclin A-associated protein in the endoplasmic reticulum	DEG_APCC_KENBOX_2	299:303	DKENV	APC,CDC20,FZR1	0.8406	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_APCC_KENBOX_2	709:713	DKENV	APC,CDC20,FZR1	0.9319	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons