DegronMD

Uniprot ID: Q9NYZ3

Source protein: G2 and S phase-expressed protein 1

Source gene: GTSE1

Class: DEG_SPOP_SBC_1

Location: 462:466

E3 ligase: SPOP

DEGRON score: 0.9636

ASA_SCORE: 83.96

COIL: 0.9304

CONS_SCORE: 0.4025

DSS_SCORE: 0.6645

HELIX: 0.0462

FCONS_SCORE: 0.9215

RIG_SCORE: 0.6182

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S476Y	TCGA-AG-A002	READ	TCGA	PDSST	DEG_SPOP_SBC_1	0.0556
p.S476Y	TCGA-DU-6392	LGG	TCGA	PDSST	DEG_SPOP_SBC_1	0.0556
p.S476Y	DO22237	LGG	ICGC	PDSST	DEG_SPOP_SBC_1	0.0556
p.D453V	TCGA-BH-A0BC	BRCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.0833
p.D453V	DO4817	BRCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0833
p.S454F	TCGA-C5-A1MH	CESC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.S454F	DO48982	CESC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.P466L	TCGA-FS-A1Z3	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.7582
p.P466L	DO37635	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.7582
p.L456I	TCGA-G2-AA3D	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.1667
p.L456I	DO51884	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1667
p.D453Y	DO233115	GACA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0833
p.Q469H	ACH-001521	Skin Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.25
p.P473S	ACH-002396	Bone Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.1389
p.P473S	Sarc9371	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons