DegronMD - O14994(SYN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A39T	TCGA-06-5416	GBM	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.A39T	TCGA-EO-A22R	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.A39T	DO10880	GBM	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.A39T	DO42713	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1389
p.Q26E	TCGA-69-7980	LUAD	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2778
p.Q26E	DO23678	LUAD	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2778
p.M40T	TCGA-85-A5B5	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.M40T	DO50102	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.R27P	TCGA-DK-AA6U	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.R27P	DO219008	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.G20D	TCGA-E6-A1LX	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.G20D	DO41020	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.M22I	TCGA-GV-A3JX	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1667
p.M22I	DO448	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1667
p.R27H	TCGA-IB-7651	PAAD	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.R27H	DO46657	PAAD	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.S37F	TCGA-YG-AA3N	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.S37F	DO51298	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.D24E	DO228948	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.2222
p.R27S	DO229027	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.3056
p.S37P	DO218842	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.S37P	DO218890	SKCA	ICGC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.R42G	SIDM00664	Pancreatic Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.0556
p.S30C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7541
p.S30C	ACH-000945	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7541
p.S30C	NCI-H650	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7541
p.T23M	SIDM00844	Burkitt's Lymphoma	GDSC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.T23M	SIDM01664	Prostate Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944
p.M40R	ACH-002186	Pancreatic Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.M40R	PL4	pancreas	COSMIC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1111
p.D31G	EN	endometrium	COSMIC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation altering degron motif	0.7198
p.R37C	SNU-175	large intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	28:32	Mutation rewiring degron network	0.1944

Kaplan plot for SYN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYN3

UniProt ID: O14994

Entrez ID: 8224

Protein name: Synapsin-3 (Synapsin III)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYN3 in