DegronMD

Uniprot ID: Q8WTP8

Source protein: Apoptosis-enhancing nuclease

Source gene: AEN

Class: DEG_SPOP_SBC_1

Location: 290:294

E3 ligase: SPOP

DEGRON score: 0.9842

ASA_SCORE: 78

COIL: 0.8756

CONS_SCORE: 0.501

DSS_SCORE: 0.6853

HELIX: 0.1006

FCONS_SCORE: 1.0812

RIG_SCORE: 0.667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W282C	TCGA-43-7656	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.W282C	DO26424	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.M300I	TCGA-GC-A3YS	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.1667
p.M300I	DO850	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM00504	Glioma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM00393	Gastric Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM00127	Oral Cavity Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM00477	Esophageal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM00928	Breast Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.C284Y	SIDM01085	Bladder Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.D302A	SIDM00462	Acute Myeloid Leukemia	GDSC	PDSST	DEG_SPOP_SBC_1	0.1111
p.D302A	ACH-000336	Leukemia	CCLE	PDSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons