DegronMD

Uniprot ID: Q6NSW7

Source protein: Homeobox protein NANOGP8

Source gene: NANOGP8

Class: DEG_SPOP_SBC_1

Location: 66:70

E3 ligase: SPOP

DEGRON score: 0.9702

ASA_SCORE: 91

COIL: 0.9488

CONS_SCORE: 0.9305

DSS_SCORE: 0.7532

HELIX: 0.0442

FCONS_SCORE: 1.272

RIG_SCORE: 0.5446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S56C	SIDM00557	Neuroblastoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.0556
p.L60P	SIDM00893	Breast Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.1667
p.L60P	BT-20	breast	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1667
p.P66L	SIDM01587	Bladder Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7582
p.M58I	KM12	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons