DegronMD

Uniprot ID: Q2M3C7

Source protein: A-kinase anchor protein SPHKAP

Source gene: SPHKAP

Class: DEG_SPOP_SBC_1

Location: 821:825

E3 ligase: SPOP

DEGRON score: 0.9316

ASA_SCORE: 83.66

COIL: 0.9024

CONS_SCORE: 0.4344

DSS_SCORE: 0.6407

HELIX: 0.0568

FCONS_SCORE: 0.8768

RIG_SCORE: 0.6198

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D822N	TCGA-BF-AAOX	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	TCGA-FS-A1Z3	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	DO37635	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	DO223907	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	SIDM00612	Glioma	GDSC	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	ACH-002257	Brain Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.5821
p.D822N	KINGS-1	central_nervous_system	COSMIC	PDSST	DEG_SPOP_SBC_1	0.5821
p.E832K	TCGA-EB-A299	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	TCGA-EB-A4IS	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	TCGA-FR-A3YO	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	DO222753	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	DO222875	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	DO47281	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	DO37794	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.E832K	DO37419	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R816H	TCGA-ZG-A8QY	PRAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.1944
p.R816H	DO51449	PRAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.D822H	DO223093	ESCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.6577
p.Y834C	DO229098	LMS	ICGC	PDSST	DEG_SPOP_SBC_1	0.0833
p.S815L	DO222632	MELA	ICGC	PDSST	DEG_SPOP_SBC_1	0.1667
p.P821S	SIDM01090	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.6752
p.P821S	ACH-000943	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.6752
p.P821S	RKO	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.6752
p.H818Y	SIDM01183	Other Solid Cancers	GDSC	PDSST	DEG_SPOP_SBC_1	0.25
p.H818Y	ACH-001417	Lung Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.25
p.H818Y	UMC-11	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.25
p.S823F	SIDM00193	Colorectal Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.7982
p.S823F	ACH-000991	Colon/Colorectal Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.7982
p.S823F	SNU-81	large_intestine	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7982
p.Q813H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PDSST	DEG_SPOP_SBC_1	0.1111
p.Q813H	ACH-000937	Leukemia	CCLE	PDSST	DEG_SPOP_SBC_1	0.1111
p.Q813H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PDSST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PDSST

Degron related mutations and impact score

Drug responses associated with SPHKAP mutations

All proteins holding degron of PDSST