DegronMD

Uniprot ID: O95425

Source protein: Supervillin

Source gene: SVIL

Class: DEG_SPOP_SBC_1

Location: 808:812

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 86.46

COIL: 0.8128

CONS_SCORE: 0.4782

DSS_SCORE: 0.5207

HELIX: 0.1672

FCONS_SCORE: 1.0211

RIG_SCORE: 0.6778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E798K	TCGA-3C-AALI	BRCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.0556
p.E798K	DO219589	BRCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.0556
p.P808H	TCGA-A5-A0G2	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.7694
p.P808H	DO41235	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.7694
p.E817K	TCGA-AX-A05Z	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1944
p.E817K	DO40884	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.S810F	TCGA-XF-AAML	BLCA	TCGA	PDSST	DEG_SPOP_SBC_1	0.7982
p.S810F	DO51933	BLCA	ICGC	PDSST	DEG_SPOP_SBC_1	0.7982
p.A803V	DO229346	LAML	ICGC	PDSST	DEG_SPOP_SBC_1	0.1944
p.S811Y	DO229026	LICA	ICGC	PDSST	DEG_SPOP_SBC_1	0.712
p.L819F	ACH-000629	Brain Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.1389
p.R806T	ChaGo-K-1	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.2778
p.R804Q	NCI-H647	lung	COSMIC	PDSST	DEG_SPOP_SBC_1	0.2222
p.R812K	TASK1	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7237

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons