DegronMD - Q00872(MYBPC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T30N	TCGA-24-1469	OV	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.T30N	DO32626	OV	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.Q50H	TCGA-49-AARE	LUAD	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.Q50H	DO218922	LUAD	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.Q50H	SIDM02014	Esophageal Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.R572Q	TCGA-A5-A0G2	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.R572Q	TCGA-BA-A6D8	HNSC	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.R572Q	DO44426	HNSC	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.R572Q	DO229123	NKTL	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.R572Q	DO41235	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.G569D	TCGA-AA-3977	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.G569D	DO8730	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0556
p.A52T	TCGA-AX-A06F	UCEC	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.A52T	DO41752	UCEC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.P579S	TCGA-BP-4167	KIRC	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6752
p.P579S	DO18799	KIRC	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6752
p.Q55K	TCGA-CN-6010	HNSC	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.0556
p.Q55K	TCGA-ER-A1A1	SKCM	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.0556
p.Q55K	DO14766	HNSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.0556
p.Q55K	DO37413	SKCM	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.0556
p.E40K	TCGA-E1-A7YI	LGG	TCGA	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.591
p.E40K	DO222884	COCA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.591
p.E40K	DO219791	LGG	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.591
p.D587Y	TCGA-NK-A5D1	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.D587Y	DO219213	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.T575A	TCGA-V1-A9Z9	PRAD	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.T575A	DO219395	PRAD	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.R591S	TCGA-W3-AA1V	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1111
p.R591S	DO51276	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1111
p.E36K	DO540	BLCA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.2778
p.A44T	DO233101	GACA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7139
p.E37K	DO14319	HNSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.3056
p.A53P	DO45440	LUSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.E38K	DO222702	MELA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7022
p.R572W	DO46333	OV	ICGC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.1389
p.L45S	SIDM02039	Colorectal Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7667
p.A33G	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.A33G	ACH-000271	Lymphoma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.A33G	SU-DHL-10	haematopoietic and lymphoid tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1944
p.K49R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.K49R	ACH-002272	Lymphoma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.K49R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.V39A	SIDM00454	Rhabdomyosarcoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.5825
p.V39A	SIDM00633	Breast Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.5825
p.R52L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.R52L	NCI-H650	lung	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.P579A	SIDM00591	Oral Cavity Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6392
p.P579A	ACH-002045	Head and Neck Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6392
p.P579A	HO-1-u-1	upper aerodigestive tract	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.6392
p.K34E	SIDM01473	Plasma Cell Myeloma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.K34E	ACH-000541	Myeloma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.P592A	HO-1-u-1	upper aerodigestive tract	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.K36R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.2778
p.S31T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1389
p.L44M	BE2-M17	autonomic ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.711
p.I49T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation substituting flanking lysine	0.3333
p.K587N	DOK	upper aerodigestive tract	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.2222
p.T579N	H-EMC-SS	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.7055
p.I35T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.L30M	BE2-M17	autonomic ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.1111
p.S44T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7116
p.S43T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7116
p.I48T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.M592I	MCC26	skin	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation rewiring degron network	0.0833
p.K35R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.25
p.I47T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.2778
p.K37R	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation rewiring degron network	0.3056
p.M580I	MCC26	skin	COSMIC	PDSST	DEG_SPOP_SBC_1	579:583	Mutation altering degron motif	0.7618
p.L43M	BE2-M17	autonomic ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.711
p.S45T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.7116
p.L42M	BE2-M17	autonomic ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	38:45	Mutation altering degron motif	0.711

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MYBPC1

UniProt ID: Q00872

Entrez ID: 4604

Protein name: Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MYBPC1 in