DegronMD

Uniprot ID: Q00872

Source protein: Myosin-binding protein C, slow-type

Source gene: MYBPC1

Class: DEG_SCF_FBW7_2

Location: 38:45

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 80.9375

COIL: 0.7694

CONS_SCORE: 0.4251

DSS_SCORE: 0.6996

HELIX: 0.108

FCONS_SCORE: 1.2143

RIG_SCORE: 0.7077

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T30N	TCGA-24-1469	OV	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.1111
p.T30N	DO32626	OV	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.1111
p.Q50H	TCGA-49-AARE	LUAD	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.Q50H	DO218922	LUAD	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.Q50H	SIDM02014	Esophageal Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.A52T	TCGA-AX-A06F	UCEC	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.1389
p.A52T	DO41752	UCEC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.1389
p.Q55K	TCGA-CN-6010	HNSC	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.0556
p.Q55K	TCGA-ER-A1A1	SKCM	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.0556
p.Q55K	DO14766	HNSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.0556
p.Q55K	DO37413	SKCM	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.0556
p.E40K	TCGA-E1-A7YI	LGG	TCGA	LVETPPGE	DEG_SCF_FBW7_2	0.591
p.E40K	DO222884	COCA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.591
p.E40K	DO219791	LGG	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.591
p.E36K	DO540	BLCA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.2778
p.A44T	DO233101	GACA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.7139
p.E37K	DO14319	HNSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.3056
p.A53P	DO45440	LUSC	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.1111
p.E38K	DO222702	MELA	ICGC	LVETPPGE	DEG_SCF_FBW7_2	0.7022
p.L45S	SIDM02039	Colorectal Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.7667
p.A33G	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.A33G	ACH-000271	Lymphoma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.A33G	SU-DHL-10	haematopoietic_and_lymphoid_tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.1944
p.K49R	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.K49R	ACH-002272	Lymphoma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.K49R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.V39A	SIDM00454	Rhabdomyosarcoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.5825
p.V39A	SIDM00633	Breast Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.5825
p.R52L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.1389
p.R52L	NCI-H650	lung	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.1389
p.K34E	SIDM01473	Plasma Cell Myeloma	GDSC	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.K34E	ACH-000541	Myeloma	CCLE	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.K36R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.2778
p.S31T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.1389
p.L44M	BE2-M17	autonomic_ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.711
p.I49T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.3333
p.I35T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.25
p.L30M	BE2-M17	autonomic_ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.1111
p.S44T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.7116
p.S43T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.7116
p.I48T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.25
p.K35R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.25
p.I47T	MCF7	breast	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.2778
p.K37R	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.3056
p.L43M	BE2-M17	autonomic_ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.711
p.S45T	LNCaP-Clone-FGC	prostate	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.7116
p.L42M	BE2-M17	autonomic_ganglia	COSMIC	LVETPPGE	DEG_SCF_FBW7_2	0.711

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVETPPGE

Degron related mutations and impact score

Drug responses associated with MYBPC1 mutations

All proteins holding degron of LVETPPGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q00872	Myosin-binding protein C, slow-type	DEG_SCF_FBW7_2	38:45	LVETPPGE	FBXW7	0.9994	More...