DegronMD

Uniprot ID: Q00872

Source protein: Myosin-binding protein C, slow-type

Source gene: MYBPC1

Class: DEG_SPOP_SBC_1

Location: 579:583

E3 ligase: SPOP

DEGRON score: 0.7592

ASA_SCORE: 56.92

COIL: 0.4314

CONS_SCORE: 0.4369

DSS_SCORE: 0.4087

HELIX: 0.0082

FCONS_SCORE: 0.8165

RIG_SCORE: 0.7335

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R572Q	TCGA-A5-A0G2	UCEC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.R572Q	TCGA-BA-A6D8	HNSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.1389
p.R572Q	DO44426	HNSC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R572Q	DO229123	NKTL	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.R572Q	DO41235	UCEC	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.G569D	TCGA-AA-3977	COAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.0556
p.G569D	DO8730	COAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.0556
p.P579S	TCGA-BP-4167	KIRC	TCGA	PDSST	DEG_SPOP_SBC_1	0.6752
p.P579S	DO18799	KIRC	ICGC	PDSST	DEG_SPOP_SBC_1	0.6752
p.D587Y	TCGA-NK-A5D1	LUSC	TCGA	PDSST	DEG_SPOP_SBC_1	0.2222
p.D587Y	DO219213	LUSC	ICGC	PDSST	DEG_SPOP_SBC_1	0.2222
p.T575A	TCGA-V1-A9Z9	PRAD	TCGA	PDSST	DEG_SPOP_SBC_1	0.2222
p.T575A	DO219395	PRAD	ICGC	PDSST	DEG_SPOP_SBC_1	0.2222
p.R591S	TCGA-W3-AA1V	SKCM	TCGA	PDSST	DEG_SPOP_SBC_1	0.1111
p.R591S	DO51276	SKCM	ICGC	PDSST	DEG_SPOP_SBC_1	0.1111
p.R572W	DO46333	OV	ICGC	PDSST	DEG_SPOP_SBC_1	0.1389
p.P579A	SIDM00591	Oral Cavity Carcinoma	GDSC	PDSST	DEG_SPOP_SBC_1	0.6392
p.P579A	ACH-002045	Head and Neck Cancer	CCLE	PDSST	DEG_SPOP_SBC_1	0.6392
p.P579A	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PDSST	DEG_SPOP_SBC_1	0.6392
p.P592A	HO-1-u-1	upper_aerodigestive_tract	COSMIC	PDSST	DEG_SPOP_SBC_1	0.0833
p.K587N	DOK	upper_aerodigestive_tract	COSMIC	PDSST	DEG_SPOP_SBC_1	0.2222
p.T579N	H-EMC-SS	bone	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7055
p.M592I	MCC26	skin	COSMIC	PDSST	DEG_SPOP_SBC_1	0.0833
p.M580I	MCC26	skin	COSMIC	PDSST	DEG_SPOP_SBC_1	0.7618

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14994	Synapsin-3	DEG_SPOP_SBC_1	28:32	PDSST	SPOP	0.9249	More...
O95425	Supervillin	DEG_SPOP_SBC_1	808:812	PDSST	SPOP	0.9671	More...
P35568	Insulin receptor substrate 1	DEG_SPOP_SBC_1	601:605	PDSST	SPOP	0.6597	More...
Q00872	Myosin-binding protein C, slow-type	DEG_SPOP_SBC_1	579:583	PDSST	SPOP	0.7592	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	821:825	PDSST	SPOP	0.9316	More...
Q6NSW7	Homeobox protein NANOGP8	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9702	More...
Q8WTP8	Apoptosis-enhancing nuclease	DEG_SPOP_SBC_1	290:294	PDSST	SPOP	0.9842	More...
Q96L73	Histone-lysine N-methyltransferase, H3 lysine-36 specific	DEG_SPOP_SBC_1	282:286	PDSST	SPOP	0.9334	More...
Q9H9S0	Homeobox protein NANOG	DEG_SPOP_SBC_1	66:70	PDSST	SPOP	0.9889	More...
Q9NYZ3	G2 and S phase-expressed protein 1	DEG_SPOP_SBC_1	462:466	PDSST	SPOP	0.9636	More...
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_SPOP_SBC_1	386:390	PDSST	SPOP	0.5318	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons