DegronMD

Uniprot ID: Q9NYZ3

Source protein: G2 and S phase-expressed protein 1

Source gene: GTSE1

Class: LIG_APCC_ABBA_1

Location: 89:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9533

ASA_SCORE: 52.6

COIL: 0.0582

CONS_SCORE: 0.692

DSS_SCORE: 0.3404

HELIX: 0.9397

FCONS_SCORE: 1.2348

RIG_SCORE: 0.8076

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P87R	TCGA-B6-A0I1	BRCA	TCGA	LALHIE	LIG_APCC_ABBA_1	0.2778
p.P87R	DO4138	BRCA	ICGC	LALHIE	LIG_APCC_ABBA_1	0.2778
p.P80S	TCGA-BH-A2L8	BRCA	TCGA	LALHIE	LIG_APCC_ABBA_1	0.0833
p.P80S	DO44242	BRCA	ICGC	LALHIE	LIG_APCC_ABBA_1	0.0833
p.F98L	TCGA-EE-A3J5	SKCM	TCGA	LALHIE	LIG_APCC_ABBA_1	0.2222
p.F98L	DO47331	SKCM	ICGC	LALHIE	LIG_APCC_ABBA_1	0.2222
p.E85K	TCGA-G7-A8LB	KIRP	TCGA	LALHIE	LIG_APCC_ABBA_1	0.2222
p.E85K	DO51553	KIRP	ICGC	LALHIE	LIG_APCC_ABBA_1	0.2222
p.V99M	TCGA-QC-A7B5	SARC	TCGA	LALHIE	LIG_APCC_ABBA_1	0.1944
p.V99M	DO220239	SARC	ICGC	LALHIE	LIG_APCC_ABBA_1	0.1944
p.K97N	DO229015	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	0.25
p.S91I	DO229027	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	0.7341
p.V99L	DO229032	LICA	ICGC	LALHIE	LIG_APCC_ABBA_1	0.1944
p.S91R	DO48719	LIRI	ICGC	LALHIE	LIG_APCC_ABBA_1	0.7427
p.P80Q	DO230934	LUSC	ICGC	LALHIE	LIG_APCC_ABBA_1	0.0833
p.P80Q	DO224581	LUSC	ICGC	LALHIE	LIG_APCC_ABBA_1	0.0833
p.P80L	SIDM00403	T-Lymphoblastic Leukemia	GDSC	LALHIE	LIG_APCC_ABBA_1	0.0833
p.P80L	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	LALHIE	LIG_APCC_ABBA_1	0.0833
p.E85D	SIDM00924	Other Solid Cancers	GDSC	LALHIE	LIG_APCC_ABBA_1	0.2222
p.E85D	ACH-000867	Lung Cancer	CCLE	LALHIE	LIG_APCC_ABBA_1	0.2222
p.E85D	ChaGo-K-1	lung	COSMIC	LALHIE	LIG_APCC_ABBA_1	0.2222
p.V101M	ACH-002693	Sarcoma	CCLE	LALHIE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NYZ3	G2 and S phase-expressed protein 1	LIG_APCC_ABBA_1	89:94	LALHIE	APC,CDC20,FZR1	0.9533	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons