DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NYQEYSIKP
Uniprot ID:
Q1X8D7
Source protein:
Leucine-rich repeat-containing protein 36
Source gene:
LRRC36
Class:
CBL_PTK
Location:
356:364
E3 ligase:
CBL
DEGRON score:
0.9804
ASA_SCORE:
101.2667
COIL:
0.7313
CONS_SCORE:
0.3953
DSS_SCORE:
0.5506
HELIX:
0.2062
FCONS_SCORE:
1.16
RIG_SCORE:
0.7158
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A372P
TCGA-49-AAR0
LUAD
TCGA
NYQEYSIKP
CBL_PTK
0.1111
p.A372T
TCGA-69-7980
LUAD
TCGA
NYQEYSIKP
CBL_PTK
0.1111
p.A372T
TCGA-E6-A1LX
UCEC
TCGA
NYQEYSIKP
CBL_PTK
0.1111
p.N356Y
TCGA-AP-A059
UCEC
TCGA
NYQEYSIKP
CBL_PTK
0.7059
p.R350K
TCGA-DU-A7T6
LGG
TCGA
NYQEYSIKP
CBL_PTK
0.1667
p.L347I
TCGA-EO-A3B0
UCEC
TCGA
NYQEYSIKP
CBL_PTK
0.0833
p.K355N
TCGA-EY-A1GD
UCEC
TCGA
NYQEYSIKP
CBL_PTK
0.3056
p.H374R
TCGA-ZF-AA52
BLCA
TCGA
NYQEYSIKP
CBL_PTK
0.0556
p.P364H
SIDM00683
Prostate Carcinoma
GDSC
NYQEYSIKP
CBL_PTK
0.7694
p.P364H
LNCaP-Clone-FGC
prostate
COSMIC
NYQEYSIKP
CBL_PTK
0.7694
p.S346L
ACH-000008
Skin Cancer
CCLE
NYQEYSIKP
CBL_PTK
0.0556
p.S346L
A101D
skin
COSMIC
NYQEYSIKP
CBL_PTK
0.0556
p.S348I
ACH-000997
Colon/Colorectal Cancer
CCLE
NYQEYSIKP
CBL_PTK
0.1111
p.S348I
ACH-001061
Colon/Colorectal Cancer
CCLE
NYQEYSIKP
CBL_PTK
0.1111
p.S348I
HCT-15
large_intestine
COSMIC
NYQEYSIKP
CBL_PTK
0.1111
p.L361F
ACH-001550
Skin Cancer
CCLE
NYQEYSIKP
CBL_PTK
0.6981
p.L361F
MCC13
skin
COSMIC
NYQEYSIKP
CBL_PTK
0.6981
Drug responses associated with LRRC36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NYQEYSIKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q1X8D7
Leucine-rich repeat-containing protein 36
CBL_PTK
356:364
NYQEYSIKP
CBL
0.9804
More...
