DegronMD

Uniprot ID: Q1X8D7

Source protein: Leucine-rich repeat-containing protein 36

Source gene: LRRC36

Class: DEG_APCC_DBOX_1

Location: 529:537

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5843

ASA_SCORE: 50.2222

COIL: 0.0247

CONS_SCORE: 0.5564

DSS_SCORE: 0.1644

HELIX: 0.975

FCONS_SCORE: 1.2555

RIG_SCORE: 0.8761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S545C	TCGA-66-2785	LUSC	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	0.1111
p.A520V	TCGA-AB-2826	LAML	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	0.0833
p.L546I	TCGA-VQ-A8E3	STAD	TCGA	LRQLLELVD	DEG_APCC_DBOX_1	0.0833
p.M534I	DO31769	OV	ICGC	LRQLLELVD	DEG_APCC_DBOX_1	0.7618
p.G542C	SIDM00127	Oral Cavity Carcinoma	GDSC	LRQLLELVD	DEG_APCC_DBOX_1	0.1944
p.G542C	ACH-002250	Head and Neck Cancer	CCLE	LRQLLELVD	DEG_APCC_DBOX_1	0.1944
p.G542C	JHU-022	upper_aerodigestive_tract	COSMIC	LRQLLELVD	DEG_APCC_DBOX_1	0.1944
p.C538S	MDA-MB-453	breast	COSMIC	LRQLLELVD	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q1X8D7	Leucine-rich repeat-containing protein 36	DEG_APCC_DBOX_1	529:537	LRQLLELVD	APC,CDC20,FZR1	0.5843	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons