DegronMD

Uniprot ID: P35568

Source protein: Insulin receptor substrate 1

Source gene: IRS1

Class: DEG_MDM2_SWIB_1

Location: 160:168

E3 ligase: MDM2

DEGRON score: 0.8327

ASA_SCORE: 51.3222

COIL: 0.2628

CONS_SCORE: 0.7812

DSS_SCORE: 0.2519

HELIX: 0.0664

FCONS_SCORE: 1.4246

RIG_SCORE: 0.923

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W164C	TCGA-51-4079	LUSC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.7
p.W164C	DO26437	LUSC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.7
p.W164L	TCGA-51-4079	LUSC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.7015
p.W164L	DO26437	LUSC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.7015
p.K177N	TCGA-A5-A2K5	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.K177N	TCGA-AJ-A3EK	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.K177N	DO41584	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.K177N	DO41379	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.V154M	TCGA-A6-5659	COAD	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1667
p.V154M	DO9860	COAD	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1667
p.K161N	TCGA-AA-3947	COAD	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.5806
p.K161N	DO8192	COAD	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.5806
p.N178K	TCGA-AP-A051	UCEC	TCGA	FKEVWQVIL	DEG_MDM2_SWIB_1	0.0556
p.N178K	DO42673	UCEC	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.0556
p.K171N	DO233882	GACA	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.3611
p.A159T	DO232761	PBCA	ICGC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.3056
p.L173P	SIDM01090	Colorectal Carcinoma	GDSC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.L173P	ACH-000943	Colon/Colorectal Cancer	CCLE	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.L173P	RKO	large_intestine	COSMIC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.1944
p.P156S	SIDM00217	Colorectal Carcinoma	GDSC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.2222
p.P156S	ACH-000999	Colon/Colorectal Cancer	CCLE	FKEVWQVIL	DEG_MDM2_SWIB_1	0.2222
p.P156S	SNU-1040	large_intestine	COSMIC	FKEVWQVIL	DEG_MDM2_SWIB_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35568	Insulin receptor substrate 1	DEG_MDM2_SWIB_1	160:168	FKEVWQVIL	MDM2	0.8327	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons