DegronMD - Q9UF56(FBXL17)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G691V	TCGA-50-5930	LUAD	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.6421
p.G691V	DO25189	LUAD	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.6421
p.A687V	TCGA-A5-A0G1	UCEC	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation rewiring degron network	0.25
p.A687V	DO42472	UCEC	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation rewiring degron network	0.25
p.P694H	TCGA-D3-A1QA	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7694
p.P694H	TCGA-E8-A2EA	THCA	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7694
p.P694H	DO47469	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7694
p.P694H	DO38926	THCA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7694
p.K681N	TCGA-DA-A1I7	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation substituting flanking lysine	0.1944
p.K681N	DO37951	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation substituting flanking lysine	0.1944
p.N695S	TCGA-DU-8167	LGG	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.5958
p.N695S	DO22608	LGG	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.5958
p.P694L	TCGA-ER-A199	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7582
p.P694L	DO47395	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.7582
p.A698V	DO8898	COAD	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation rewiring degron network	0.3056
p.Q95H	DO8706	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.7582
p.L16R	DO50338	ESAD	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation substituting flanking lysine	0.1667
p.L94S	DO233156	GACA	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.7667
p.A698S	DO233219	GACA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation rewiring degron network	0.3056
p.P85R	DO14236	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1111
p.A687D	DO229034	LICA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation rewiring degron network	0.25
p.M99T	DO44806	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.2778
p.D107Y	DO23774	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0556
p.Y19C	DO51196	LUAD	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1389
p.A21T	DO232761	PBCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.A21T	DO41752	UCEC	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1944
p.V105A	DO48032	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1111
p.R27Q	DO229272	THCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation altering degron motif	0.7329
p.R36Q	DO229213	THCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.2778
p.R103H	DO229250	THCA	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1667
p.V86I	DO41638	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1389
p.R96M	DO42713	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation altering degron motif	0.8632
p.C20S	SIDM00594	Acute Myeloid Leukemia	GDSC	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.C20S	ACH-000004	Leukemia	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.C20S	ACH-000005	Leukemia	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.1667
p.R102Q	SIDM00068	Colorectal Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.1944
p.W692C	ACH-000454	Lung Cancer	CCLE	MGWTPNMS	DEG_SCF_FBW7_1	690:697	Mutation altering degron motif	0.5889
p.Q44E	ACH-000961	Endometrial/Uterine Cancer	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.0556
p.R35H	ACH-000963	Colon/Colorectal Cancer	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	26:34	Mutation rewiring degron network	0.3056
p.A107T	SNU-1040	large intestine	COSMIC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0556
p.A107T	COLO-684	endometrium	COSMIC	AASSS	DEG_SPOP_SBC_1	93:97	Mutation rewiring degron network	0.0556

Kaplan plot for FBXL17 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXL17

UniProt ID: Q9UF56

Entrez ID: 64839

Protein name: F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXL17 in