DegronMD

Uniprot ID: Q9UF56

Source protein: F-box/LRR-repeat protein 17

Source gene: FBXL17

Class: DEG_APCC_DBOX_1

Location: 26:34

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7204

ASA_SCORE: 120.3778

COIL: 0.8967

CONS_SCORE: 0.2825

DSS_SCORE: 0.41

HELIX: 0.0656

FCONS_SCORE: 1.058

RIG_SCORE: 0.7437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L16R	DO50338	ESAD	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.1667
p.Y19C	DO51196	LUAD	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.1389
p.A21T	DO232761	PBCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.1944
p.A21T	DO41752	UCEC	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.1944
p.R27Q	DO229272	THCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.7329
p.R36Q	DO229213	THCA	ICGC	RRRPLLRLP	DEG_APCC_DBOX_1	0.2778
p.C20S	SIDM00594	Acute Myeloid Leukemia	GDSC	RRRPLLRLP	DEG_APCC_DBOX_1	0.1667
p.C20S	ACH-000004	Leukemia	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	0.1667
p.C20S	ACH-000005	Leukemia	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	0.1667
p.Q44E	ACH-000961	Endometrial/Uterine Cancer	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	0.0556
p.R35H	ACH-000963	Colon/Colorectal Cancer	CCLE	RRRPLLRLP	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UF56	F-box/LRR-repeat protein 17	DEG_APCC_DBOX_1	26:34	RRRPLLRLP	APC,CDC20,FZR1	0.7204	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons