DegronMD

Uniprot ID: Q9UF56

Source protein: F-box/LRR-repeat protein 17

Source gene: FBXL17

Class: DEG_SCF_FBW7_1

Location: 690:697

E3 ligase: FBXW7

DEGRON score: 0.733

ASA_SCORE: 71.8

COIL: 0.8343

CONS_SCORE: 0.417

DSS_SCORE: 0.4712

HELIX: 0.1463

FCONS_SCORE: 1.0966

RIG_SCORE: 0.7509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G691V	TCGA-50-5930	LUAD	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.6421
p.G691V	DO25189	LUAD	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.6421
p.A687V	TCGA-A5-A0G1	UCEC	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.25
p.A687V	DO42472	UCEC	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.25
p.P694H	TCGA-D3-A1QA	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.7694
p.P694H	TCGA-E8-A2EA	THCA	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.7694
p.P694H	DO47469	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.7694
p.P694H	DO38926	THCA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.7694
p.K681N	TCGA-DA-A1I7	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.1944
p.K681N	DO37951	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.1944
p.N695S	TCGA-DU-8167	LGG	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.5958
p.N695S	DO22608	LGG	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.5958
p.P694L	TCGA-ER-A199	SKCM	TCGA	MGWTPNMS	DEG_SCF_FBW7_1	0.7582
p.P694L	DO47395	SKCM	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.7582
p.A698V	DO8898	COAD	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.3056
p.A698S	DO233219	GACA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.3056
p.A687D	DO229034	LICA	ICGC	MGWTPNMS	DEG_SCF_FBW7_1	0.25
p.W692C	ACH-000454	Lung Cancer	CCLE	MGWTPNMS	DEG_SCF_FBW7_1	0.5889

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UF56	F-box/LRR-repeat protein 17	DEG_SCF_FBW7_1	690:697	MGWTPNMS	FBXW7	0.733	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons