DegronMD - Q5BKY9(FAM133B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S185Y	TCGA-A5-A0G1	UCEC	TCGA	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation altering degron motif	0.6009
p.S185Y	DO42472	UCEC	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation altering degron motif	0.6009
p.S191P	TCGA-EO-A22X	UCEC	TCGA	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation blocking phosphorylation signal	0.6389
p.S191P	DO43907	UCEC	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation blocking phosphorylation signal	0.6389
p.S191L	DO225395	BRCA	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation blocking phosphorylation signal	0.6389
p.E186K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation altering degron motif	0.7022
p.E186K	ACH-000995	Leukemia	CCLE	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation altering degron motif	0.7022
p.E186K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation altering degron motif	0.7022
p.S241C	SIDM00673	Breast Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7541
p.S241C	ACH-000668	Breast Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7541
p.S241C	HCC70	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7541
p.E176K	Jurkat	haematopoietic and lymphoid tissue	COSMIC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	180:186	Mutation rewiring degron network	0.2222
p.S231C	HCC70	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons