DegronMD

Uniprot ID: Q5BKY9

Source protein: Protein FAM133B

Source gene: FAM133B

Class: LIG_APCC_ABBAyCdc20_2

Location: 180:186

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.76

ASA_SCORE: 119.7143

COIL: 0.7479

CONS_SCORE: 0.3178

DSS_SCORE: 0.5361

HELIX: 0.1946

FCONS_SCORE: 0.9639

RIG_SCORE: 0.6965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S185Y	TCGA-A5-A0G1	UCEC	TCGA	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.6009
p.S185Y	DO42472	UCEC	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.6009
p.S191P	TCGA-EO-A22X	UCEC	TCGA	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S191P	DO43907	UCEC	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S191L	DO225395	BRCA	ICGC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.6389
p.E186K	SIDM01016	T-Lymphoblastic Leukemia	GDSC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E186K	ACH-000995	Leukemia	CCLE	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E186K	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E176K	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	KRKMYSE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5BKY9	Protein FAM133B	LIG_APCC_ABBAyCdc20_2	180:186	KRKMYSE	APC,CDC20,FZR1	0.76	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons