DegronMD - Q8NFJ9(BBS1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q506H	TCGA-28-1752	GBM	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1944
p.Q506H	DO12388	GBM	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1944
p.R512C	TCGA-2W-A8YY	CESC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8301
p.R512C	TCGA-EO-A22R	UCEC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8301
p.R512C	DO223732	CESC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8301
p.R512C	DO42713	UCEC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8301
p.Q421H	TCGA-AD-6964	COAD	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.0833
p.Q421H	DO8360	COAD	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.0833
p.N426I	TCGA-AP-A051	UCEC	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.2222
p.N426I	DO42673	UCEC	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.2222
p.R440Q	TCGA-AZ-6601	COAD	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.2222
p.R440Q	DO8119	COAD	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.2222
p.D8N	TCGA-BP-5182	KIRC	TCGA	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.D8N	DO18552	KIRC	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.3056
p.R512H	TCGA-DS-A0VN	CESC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8244
p.R512H	DO6269	CESC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.8244
p.S5F	TCGA-EE-A2MI	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7982
p.S5F	DO37531	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7982
p.P513S	TCGA-FS-A1ZK	SKCM	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.5641
p.P513S	DO37474	SKCM	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.5641
p.E15K	TCGA-G2-A2EO	BLCA	TCGA	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1111
p.E15K	DO456	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1111
p.M423I	TCGA-GR-A4D4	DLBC	TCGA	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.1389
p.M423I	DO219907	DLBC	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.1389
p.S9Y	TCGA-HR-A2OG	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.S9Y	DO37511	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.L518V	TCGA-SC-A6LN	MESO	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.5654
p.G4R	DO452	BLCA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7568
p.E15Q	DO218173	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.1111
p.G4A	DO2836	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.754
p.P443L	DO5535	BRCA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.1389
p.S9T	DO50319	ESAD	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2778
p.S2I	DO12046	GBM	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation substituting flanking lysine	0.4167
p.M17L	DO228278	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0556
p.M17I	DO228948	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.0556
p.V442L	DO229025	LICA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.1667
p.V442L	DO229045	LICA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.1667
p.E525K	DO229058	LICA	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1667
p.A11P	DO52393	LIHM	ICGC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation rewiring degron network	0.2222
p.N426S	DO35270	PACA	ICGC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation rewiring degron network	0.2222
p.R512S	SIDM00501	Oral Cavity Carcinoma	GDSC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.7427
p.R512S	BICR78	upper aerodigestive tract	COSMIC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation altering degron motif	0.7427
p.L505P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1667
p.L505P	NCI-H1648	lung	COSMIC	TRPVLGLLV	DEG_APCC_DBOX_1	511:519	Mutation rewiring degron network	0.1667
p.A4T	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.6028
p.A4T	ACH-000865	Esophageal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.6028
p.A4T	KYSE-450	oesophagus	COSMIC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.6028
p.S6L	SIDM00996	Thyroid Gland Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7667
p.S6L	ACH-001307	Thyroid Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7667
p.S6L	8505C	thyroid	COSMIC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7667
p.K430N	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation altering degron motif	0.6918
p.K430N	RC-K8	haematopoietic and lymphoid tissue	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation altering degron motif	0.6918
p.A3S	ACH-000554	Breast Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7588
p.A3S	UACC-893	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	3:7	Mutation altering degron motif	0.7588
p.P434L	HDQ-P1	breast	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation altering degron motif	0.7582
p.R435L	SK-GT-2	stomach	COSMIC	KTRLYVD	LIG_APCC_ABBAyCdc20_2	430:436	Mutation altering degron motif	0.8428

Kaplan plot for BBS1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BBS1

UniProt ID: Q8NFJ9

Entrez ID: 582

Protein name: Bardet-Biedl syndrome 1 protein (BBS2-like protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BBS1 in