DegronMD

Uniprot ID: Q8NFJ9

Source protein: Bardet-Biedl syndrome 1 protein

Source gene: BBS1

Class: DEG_APCC_DBOX_1

Location: 511:519

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5373

ASA_SCORE: 54.5444

COIL: 0.6616

CONS_SCORE: 0.3762

DSS_SCORE: 0.0146

HELIX: 0.0242

FCONS_SCORE: 0.8519

RIG_SCORE: 0.9376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q506H	TCGA-28-1752	GBM	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.1944
p.Q506H	DO12388	GBM	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.1944
p.R512C	TCGA-2W-A8YY	CESC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.8301
p.R512C	TCGA-EO-A22R	UCEC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.8301
p.R512C	DO223732	CESC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.8301
p.R512C	DO42713	UCEC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.8301
p.R512H	TCGA-DS-A0VN	CESC	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.8244
p.R512H	DO6269	CESC	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.8244
p.P513S	TCGA-FS-A1ZK	SKCM	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.5641
p.P513S	DO37474	SKCM	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.5641
p.L518V	TCGA-SC-A6LN	MESO	TCGA	TRPVLGLLV	DEG_APCC_DBOX_1	0.5654
p.E525K	DO229058	LICA	ICGC	TRPVLGLLV	DEG_APCC_DBOX_1	0.1667
p.R512S	SIDM00501	Oral Cavity Carcinoma	GDSC	TRPVLGLLV	DEG_APCC_DBOX_1	0.7427
p.R512S	BICR78	upper_aerodigestive_tract	COSMIC	TRPVLGLLV	DEG_APCC_DBOX_1	0.7427
p.L505P	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	TRPVLGLLV	DEG_APCC_DBOX_1	0.1667
p.L505P	NCI-H1648	lung	COSMIC	TRPVLGLLV	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFJ9	Bardet-Biedl syndrome 1 protein	DEG_APCC_DBOX_1	511:519	TRPVLGLLV	APC,CDC20,FZR1	0.5373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons